COL12A1 and MYBPC2

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		COL12A1	MYBPC2
Name		collagen type XII alpha 1 chain	myosin binding protein C2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Cytosol M Band Myosin Filament
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Actin Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Cell Adhesion Tissue Development Collagen Fibril Organization Endodermal Cell Differentiation	Cell Adhesion Sarcomere Organization
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Striated Muscle Contraction
GWAS		Central corneal thickness ( 29760442 32528159 ) Joint mobility (Beighton score) ( 27182965 ) Keratoconus ( 33649486 ) Systemic juvenile idiopathic arthritis ( 27927641 )	Primary biliary cholangitis ( 26394269 )
Interacting Genes		4 interacting genes: DYSF HSP90AA1 MYBPC2 WDR37	31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3
Entrez ID		1303	4606
HPRD ID		00377	01184
Ensembl ID		ENSG00000111799	ENSG00000086967
Uniprot IDs		Q99715	A0A140VJQ0 Q14324
PDB IDs		Not available	2E7C 2EDK 2EDN
GO Terms Enriched among Interactors		CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Monocyte Activation Involved In Immune Response Rho GDP-dissociation Inhibitor Binding Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly	Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport