COX2 and HRSP12

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		COX2	HRSP12
Gene Name		cytochrome c oxidase subunit II	heat-responsive protein 12
Image
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Mitochondrion Extracellular Vesicular Exosome
	Molecular Function		Endonuclease Activity Deaminase Activity Poly(A) RNA Binding
	Biological Process		Regulation Of Translational Termination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs			Benzoic Acid
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: CCNG1 ECT2 EGFR HRSP12 LIG4 PSMA1 RAD21 YWHAE	9 interactors: COX2 DEAF1 HIVEP1 HPD MDM2 SERPINA5 SPEN TMEM176A TRIB3
Entrez ID		4513	10247
HPRD ID		02470	03924
Ensembl ID			ENSG00000132541
Uniprot IDs		P00403 Q7GXZ8	P52758
PDB IDs		3VRJ	1ONI
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Apoptotic Process Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Death Apoptotic Process Cell Division Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cell Death Death Response To Stress Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Response To Metal Ion Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Central Nervous System Development Negative Regulation Of Cell Death Positive Regulation Of Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Regulation Of Intracellular Transport Alkanesulfonate Metabolic Process DNA Ligation Involved In DNA Recombination Negative Regulation Of Cell Cycle Response To Radiation Nervous System Development Response To Inorganic Substance Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Positive Regulation Of Protein Import Into Nucleus Regulation Of Fibroblast Proliferation Positive Regulation Of Signal Transduction Mitotic DNA Integrity Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Viral Process Response To Calcium Ion	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Response To Light Stimulus Cellular Response To UV Maintenance Of Blood-brain Barrier Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Fatty Acid Metabolic Process Response To Radiation Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Vitamin Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Oxygen Levels Defense Response Regulation Of Fat Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Production Response To UV Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Learning Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Gamete Generation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Differentiation Tyrosine Catabolic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Dendritic Cell Differentiation Response To Carbohydrate Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Tagcloud ?		cadherin cancers cd44 center character characteristics chi2 clinic colon colorectal differentiated feature features gender histological hmlh1 hmsh2 ki meanwhile mucinous protection rates rectal right shanghai sided signet subsides vs
Tagcloud (Difference) ?		cadherin cancers cd44 center character characteristics chi2 clinic colon colorectal differentiated feature features gender histological hmlh1 hmsh2 ki meanwhile mucinous protection rates rectal right shanghai sided signet subsides vs
Tagcloud (Intersection) ?