MT-CO2 and RAD21

Number of citations of the paper that reports this interaction (PubMedID 22145905)
0

Data Source:
BioGRID (two hybrid)

		MT-CO2	RAD21
Description		cytochrome c oxidase subunit II	RAD21 cohesin complex component
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Cytochrome-c Oxidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Metal Ion Binding	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, Cytochrome C To Oxygen Lactation Electron Transport Chain ATP Synthesis Coupled Electron Transport Cellular Respiration Response To Ethanol Proton Transmembrane Transport	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs		Cholic Acid N-Formylmethionine Talmapimod
Diseases
GWAS			Menopause (age at onset) ( 29773799)
Interacting Genes		11 interacting genes: CCNG1 ECT2 EGFR HSPB2 LIG4 PSMA1 RAD21 RIDA SHANK3 VHL YWHAE	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		4513	5885
HPRD ID		02470	05924
Ensembl ID		ENSG00000198712	ENSG00000164754
Uniprot IDs		P00403 U5Z487	O60216
PDB IDs		3VRJ 5Z62	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		Cell Division Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cell Morphogenesis Nucleus Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Cell Cycle Process Positive Regulation Of Fibroblast Proliferation Multivesicular Body, Internal Vesicle Lumen MAPK Cascade Establishment Of Integrated Proviral Latency 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Positive Regulation Of Nucleocytoplasmic Transport Cytoplasm Regulation Of Protein Phosphorylation Centralspindlin Complex Cellular Response To Stress Cellular Response To Ionizing Radiation Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Differentiation Cytosol Enzyme Binding Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Response To Heat DNA Ligase (ATP) Activity DNA Ligase IV Complex Establishment Of Viral Latency DNA Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Meiotic Sister Chromatid Cohesion Regulation Of Heart Rate By Hormone Scaffold Protein Binding L-threonine Catabolic Process Threonine Metabolic Process Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Chromosome Organization	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly
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