MC5R and AGRP

Number of citations: 0 (PubMedID 9892020)
Data Source: HPRD (in vitro)

		MC5R	AGRP
Name		melanocortin 5 receptor	agouti related neuropeptide
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Protein Binding Hormone Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Type 1 Melanocortin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Bremelanotide	None
GWAS		Depression in smokers ( 30219690 ) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )	Blood protein levels ( 30072576 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 )
Interacting Genes		3 interacting genes: AGRP ASIP POMC	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		4161	181
HPRD ID		08965	09079
Ensembl ID		ENSG00000176136	ENSG00000159723
Uniprot IDs		P33032	C6SUN5 O00253
PDB IDs		8INR 8IOD	1HYK 1MR0
GO Terms Enriched among Interactors		Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Feeding Behavior Neuropeptide Signaling Pathway Long-day Photoperiodism Melanocortin Receptor Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Extracellular Space Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Response To Peptide Hormone Generation Of Precursor Metabolites And Energy Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Melanin Biosynthetic Process Extracellular Region Positive Regulation Of Feeding Behavior Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Response To Hormone Pigment Granule Localization Pigment Granule Transport Establishment Of Melanosome Localization Signaling Cell Communication Melanosome Localization Cell-cell Signaling Melanosome Transport Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Positive Regulation Of Behavior Eating Behavior Maternal Process Involved In Female Pregnancy Epigenetic Programming Of Gene Expression G Protein-coupled Receptor Signaling Pathway Melanosome Organization	Melanocortin Receptor Activity Regulation Of Feeding Behavior Melanocyte-stimulating Hormone Receptor Activity Regulation Of Behavior Regulation Of Eating Behavior Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Secretion Peptide Secretion Feeding Behavior Hormone Transport Hormone Secretion Peptide Transport Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Homoiothermy Amide Transport Response To Melanocyte-stimulating Hormone Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Blood Circulation Growth Hormone Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Corticotropin Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Gastric Acid Secretion Positive Regulation Of Growth Hormone Secretion