MC5R

Name	melanocortin 5 receptor
Structure
Interactors	3 interactors: AGRP ASIP POMC
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Protein Binding Hormone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs	Bremelanotide
GWAS	Depression in smokers ( 30219690 ) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )
Entrez ID	4161
HPRD ID	08965
Ensembl ID	ENSG00000176136
Uniprot IDs	P33032
PDB IDs	8INR 8IOD
GO Terms Enriched among Interactors ?	Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Feeding Behavior Neuropeptide Signaling Pathway Long-day Photoperiodism Melanocortin Receptor Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Extracellular Space Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Response To Peptide Hormone Generation Of Precursor Metabolites And Energy Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Melanin Biosynthetic Process Extracellular Region Positive Regulation Of Feeding Behavior Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Response To Hormone Pigment Granule Localization Pigment Granule Transport Establishment Of Melanosome Localization Signaling Cell Communication Melanosome Localization Cell-cell Signaling Melanosome Transport Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Positive Regulation Of Behavior Eating Behavior Maternal Process Involved In Female Pregnancy Epigenetic Programming Of Gene Expression G Protein-coupled Receptor Signaling Pathway Melanosome Organization