ARFIP1 and SMPD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARFIP1	SMPD2
Description		ARF interacting protein 1	sphingomyelin phosphodiesterase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Membrane Trans-Golgi Network Membrane	Endoplasmic Reticulum Plasma Membrane Caveola Membrane Cell Periphery
	Molecular Function	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding	Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Intracellular Protein Transport Intracellular Protein Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process
Pathways			Ceramide signalling TNFR1-mediated ceramide production Glycosphingolipid catabolism
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Height ( 18391951)
Interacting Genes		18 interacting genes: AFF1 ARF1 ARF3 ARF5 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D	15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31
Entrez ID		27236	6610
HPRD ID		09331	04608
Ensembl ID		ENSG00000164144	ENSG00000135587
Uniprot IDs		B4E273 P53367 Q8N8M9	O60906
PDB IDs			8J2F
Enriched GO Terms of Interacting Partners?
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