MGST1 and VIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MGST1	VIP
Description		microsomal glutathione S-transferase 1	vasoactive intestinal peptide
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Azurophil Granule Membrane	Extracellular Region Extracellular Space Neuron Projection
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Transferase Activity	Hormone Activity Neuropeptide Hormone Activity Protein Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Glutathione Transport Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification	Response To Yeast G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Positive Regulation Of Cell Population Proliferation Antibacterial Humoral Response Antifungal Humoral Response Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Protein Catabolic Process Epinephrine Secretion MRNA Stabilization Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Prolactin Secretion Positive Regulation Of CAMP/PKA Signal Transduction
Pathways		Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Glutathione Glutathione disulfide
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bell's palsy ( 33602968) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Mild age-related type 2 diabetes ( 34737425) Visceral fat ( 22589738)	Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600)
Interacting Genes		8 interacting genes: EGF FXYD3 FZD7 LTC4S NELFB SIGLEC12 TNFRSF10C VIP	11 interacting genes: CTNNA3 MEOX2 MEP1A MGST1 MME PRICKLE1 SGTA UBQLN2 UBQLN4 VIPR1 VIPR2
Entrez ID		4257	7432
HPRD ID		00705	15950
Ensembl ID		ENSG00000008394	ENSG00000146469
Uniprot IDs		F5H613 P10620	P01282
PDB IDs			2RRH 2RRI 8E3Z
Enriched GO Terms of Interacting Partners?			Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Peptide Hormone Processing Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Catabolic Process G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Signaling Receptor Ligand Precursor Processing Limb Development Proteolysis Cellular Response To Lipid Hydroperoxide Neuropeptide Processing Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Creatinine Metabolic Process TRC Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Metalloendopeptidase Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Response To Lipid Hydroperoxide Substance P Catabolic Process Negative Regulation Of Autophagosome Maturation Extracellular Matrix Constituent Secretion Tear Secretion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Exopeptidase Activity BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Embryonic Nail Plate Morphogenesis Somite Specification
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