MGST1 and NELFB

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		MGST1	NELFB
Description		microsomal glutathione S-transferase 1	negative elongation factor complex member B
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Azurophil Granule Membrane	Nucleus Nucleoplasm Cytoplasm NELF Complex
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Transferase Activity	RNA Binding Protein Binding
	Biological Process	Glutathione Transport Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification	Cell Population Proliferation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Negative Regulation Of Stem Cell Differentiation
Pathways		Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation NTRK3 as a dependence receptor
Drugs		Glutathione Glutathione disulfide
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bell's palsy ( 33602968) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Mild age-related type 2 diabetes ( 34737425) Visceral fat ( 22589738)
Interacting Genes		8 interacting genes: EGF FXYD3 FZD7 LTC4S NELFB SIGLEC12 TNFRSF10C VIP	15 interacting genes: BRCA1 CEBPA CEBPE DENR ESR1 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFE NTRK3 RAD51 TPRX1
Entrez ID		4257	25920
HPRD ID		00705	10845
Ensembl ID		ENSG00000008394	ENSG00000188986
Uniprot IDs		F5H613 P10620	Q8WX92
PDB IDs			6GML 7PKS 7YCX 8JJ6 8RBX 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?			Integrated Stress Response Signaling Chromatin Binding Chromatin Myeloid Cell Differentiation Response To Lipid RNA Polymerase II Transcription Regulator Complex Nucleoplasm Nuclear Ubiquitin Ligase Complex Myeloid Leukocyte Differentiation Transcription Factor AP-1 Complex Cellular Response To Oxygen-containing Compound Enzyme Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Steroid Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleus Protein-containing Complex Cellular Response To Lipid Lateral Element Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Tumor Necrosis Factor Response To Alcohol Response To Corticosterone Positive Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Response To Xenobiotic Stimulus Positive Regulation Of RNA Metabolic Process Response To Tumor Necrosis Factor Regulation Of DNA Damage Checkpoint Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Mononuclear Cell Differentiation Response To Glucocorticoid Response To Hormone Double-stranded DNA Binding Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Granulocyte Differentiation Nuclear Chromosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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