MGST1 and LTC4S

Number of citations of the paper that reports this interaction (PMID 11034337)
2

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		MGST1	LTC4S
Gene Name		microsomal glutathione S-transferase 1	leukotriene C4 synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Apical Part Of Cell	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Response To Organonitrogen Compound Response To Lipopolysaccharide Leydig Cell Differentiation Response To Drug Small Molecule Metabolic Process Oxidation-reduction Process Protein Homotrimerization Cellular Response To Lipid Hydroperoxide Glutathione Derivative Biosynthetic Process	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs			Glutathione
Diseases
GWAS		Visceral fat ( 22589738)
Protein-Protein Interactions		2 interactors: LTC4S NELFB	3 interactors: ALOX5 ALOX5AP MGST1
Entrez ID		4257	4056
HPRD ID		00705	02004
Ensembl ID		ENSG00000008394	ENSG00000213316
Uniprot IDs		P10620	Q16873
PDB IDs			2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV
Enriched GO Terms of Interacting Partners?		Lipoxin Metabolic Process Lipoxygenase Pathway	Lipoxin Metabolic Process Lipoxygenase Pathway Protein Homotrimerization Leukotriene Biosynthetic Process Protein Trimerization Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Cellular Response To Lipid Hydroperoxide Leukotriene Production Involved In Inflammatory Response Protein Homooligomerization Response To Lipid Hydroperoxide Fatty Acid Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hydroperoxide Leydig Cell Differentiation Response To Hydroperoxide Glutathione Derivative Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Cellular Lipid Metabolic Process Protein Complex Assembly Carboxylic Acid Metabolic Process Cellular Response To Calcium Ion Organic Acid Metabolic Process Lipid Metabolic Process Biosynthetic Process Glutathione Metabolic Process Oxidation-reduction Process Response To Calcium Ion Cellular Response To Metal Ion Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Inorganic Substance Cellular Component Assembly Response To Xenobiotic Stimulus Peptide Metabolic Process Male Gonad Development Male Sex Differentiation Cellular Response To Oxidative Stress Gonad Development Development Of Primary Sexual Characteristics Cellular Modified Amino Acid Metabolic Process
Tagcloud ?		analyse arsenate arsenic asenic carboxymethylenebutenolidase cmbl disturbed elusive etc ferrintin frh3 hub ingenity inorganic medaka metalloid microsomal million nr2f2 ontology pollutant sage slc40a1 solute tags tpm transcriptome transcripts zebrafish	apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b
Tagcloud (Difference) ?		analyse arsenate arsenic asenic carboxymethylenebutenolidase cmbl disturbed elusive etc ferrintin frh3 hub ingenity inorganic medaka metalloid microsomal million nr2f2 ontology pollutant sage slc40a1 solute tags tpm transcriptome transcripts zebrafish	apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b
Tagcloud (Intersection) ?