GDI2 and RAB9A

Number of citations: 77 (PubMedID 38334954)
Data Source: BioGRID (cross-linking study), HPRD (in vitro)

		GDI2	RAB9A
Name		GDP dissociation inhibitor 2	RAB9A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome	Golgi Membrane Lysosome Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Melanosome Phagocytic Vesicle Extracellular Exosome
	Molecular Function	RNA Binding GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Identical Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Negative Regulation Of Cilium Assembly Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization	Receptor-mediated Endocytosis Protein Transport Rab Protein Signal Transduction Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of Exocytosis
Pathways		Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs	Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs RHOBTB3 ATPase cycle
Drugs		None	Guanosine-5'-Diphosphate
GWAS		Blood protein levels ( 30072576 ) Cutaneous malignant melanoma ( 32341527 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Osteosarcoma ( 23727862 )	Red cell distribution width ( 32888494 )
Novel Interactors		1 novel interactors: GATA3	None recorded
Interacting Genes		12 interacting genes: CEBPA GLRA2 HSPB1 LINC00632 LINC01554 OGT RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A	8 interacting genes: BCL3 GDI1 GDI2 PLIN3 RABEPK RHOBTB3 TM9SF2 TRIM14
Entrez ID		2665	9367
HPRD ID		02863	02236
Ensembl ID		ENSG00000057608	ENSG00000123595
Uniprot IDs		P50395 Q6IAT1	P51151
PDB IDs		Not available	1WMS 7E1T
GO Terms Enriched among Interactors		GDP Binding G Protein Activity GTPase Activity GTP Binding Phagocytic Vesicle Regulation Of Long-term Neuronal Synaptic Plasticity Protein Transport Receptor Localization To Synapse Protein Localization To Synapse Intracellular Protein Localization Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Clearance By Transcytosis Establishment Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Plasma Membrane To Endosome Transport Establishment Of Protein Localization To Postsynaptic Membrane Phagocytic Vesicle Membrane Neurotransmitter Receptor Transport To Plasma Membrane HMG Box Domain Binding Protein Localization To Cell Junction Endosomal Transport Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Recycling Endosome Membrane Melanosome Myosin V Binding Trans-Golgi Network Membrane Rab Protein Signal Transduction Transcytosis Vesicle-mediated Transport Intracellular Transport Recycling Endosome Endosome Amyloid-beta Clearance Membrane Fusion Protein Localization To Postsynaptic Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Membrane Protein Localization To Postsynapse Extracellular Exosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding Modulation Of Chemical Synaptic Transmission Vesicle Docking Involved In Exocytosis Regulation Of Synaptic Plasticity Cellular Localization Establishment Of Localization In Cell Macrophage Differentiation	Rab GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Golgi Apparatus Small GTPase Binding Endosome Membrane Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Cytoplasm Follicular Dendritic Cell Differentiation Transport Vesicle Trans-Golgi Network Membrane Follicular Dendritic Cell Activation Negative Regulation Of Protein Localization To Cilium Positive Regulation Of Triglyceride Storage Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process