GDI2 and RAB8A

Number of citations of the paper that reports this interaction (PMID 10512627)
11

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GDI2	RAB8A
Gene Name		GDP dissociation inhibitor 2	RAB8A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Extracellular Vesicular Exosome	Golgi Membrane Nucleus Nucleoplasm Nucleolus Centrosome Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Nonmotile Primary Cilium Ciliary Basal Body Neuronal Cell Body Phagocytic Vesicle Recycling Endosome Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Rab GDP-dissociation Inhibitor Activity Rab GTPase Activator Activity Protein Binding Small GTPase Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding GDP Binding Protein Kinase Binding Myosin V Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of Rab GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Organelle Organization Axonogenesis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Cilium Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Membrane Organization Protein Localization To Plasma Membrane
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium G2/M Transition Assembly of the primary cilium Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Osteosarcoma ( 23727862)
Protein-Protein Interactions		7 interactors: GLRA2 RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A	20 interactors: BAG6 BIRC6 GDI2 MAP4K2 MDM2 MYO5B MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		2665	4218
HPRD ID		02863	01296
Ensembl ID		ENSG00000057608
Uniprot IDs		E7EU23 P50395 Q6IAT1	B4DEK7 P61006
PDB IDs			3QBT 3TNF
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Neuronal Synaptic Plasticity Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Cellular Localization Regulation Of Exocytosis Regulation Of Synaptic Plasticity Transport Establishment Of Vesicle Localization Endosomal Transport Vesicle Localization Signal Transduction Signaling Cell Communication Regulation Of Synaptic Transmission Establishment Of Organelle Localization Cellular Response To Stimulus Positive Regulation Of Exocytosis Organelle Localization Endomembrane System Organization Multivesicular Body Assembly Regulation Of Multivesicular Body Size Vesicle-mediated Transport Synaptic Vesicle Transport Multivesicular Body Organization Response To Stimulus Regulation Of Secretion Protein Localization To Plasma Membrane Golgi Vesicle Fusion To Target Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Mitotic Cell Cycle Exosomal Secretion Regulation Of Endocytosis Membrane Organization Plasma Membrane Organization Plasma Membrane To Endosome Transport Astral Microtubule Organization Regulation Of Cellular Localization Positive Regulation Of Secretion	Establishment Of Protein Localization Protein Localization Protein Transport Vesicle-mediated Transport Cellular Protein Localization Cellular Localization Intracellular Protein Transport Transport Establishment Of Localization In Cell Intracellular Transport Exocytosis Regulation Of Exocytosis Regulation Of Catalytic Activity Golgi To Plasma Membrane Transport Regulation Of Signaling Intracellular Signal Transduction Secretion By Cell Protein Localization To Organelle Cellular Response To UV-C Cellular Response To Vitamin B1 Establishment Of Protein Localization To Membrane Regulation Of Signal Transduction Cell Cycle Process Secretion Mitotic Cell Cycle Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Organelle Organization Post-Golgi Vesicle-mediated Transport Positive Regulation Of GTPase Activity Negative Regulation Of Proteolysis Mitotic Cell Cycle Protein Localization To Membrane Negative Regulation Of Protein Processing Traversing Start Control Point Of Mitotic Cell Cycle Multivesicular Body Sorting Pathway Negative Regulation Of Receptor Recycling Regulation Of Vesicle-mediated Transport Regulation Of GTPase Activity Response To Vitamin B1 Response To Ether Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Signal Transduction By P53 Class Mediator Cell Cycle Regulation Of Protein Processing G2/M Transition Of Mitotic Cell Cycle Membrane Organization Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity
Tagcloud ?		actb aldoa aldr catb catd catg co3 conceptus cst6 gd1b gda gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	apical assemble cdc42 directs exchange exocyst exocytosis gef generate guanine hypothesized interconnection lumen machineries must novo organs par3 polarity polarization polarize polarized rab11a rabin8 revealing traffic tuba vesicular
Tagcloud (Difference) ?		actb aldoa aldr catb catd catg co3 conceptus cst6 gd1b gda gsn hsp7c hsp90a hsp90a1 hspa8 idhc ifnt itraq phosphorylase pnp pnph ret4 rpb4 serpina31 tera timp2 ulf vcn	apical assemble cdc42 directs exchange exocyst exocytosis gef generate guanine hypothesized interconnection lumen machineries must novo organs par3 polarity polarization polarize polarized rab11a rabin8 revealing traffic tuba vesicular
Tagcloud (Intersection) ?