TPD52L1 and ABL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TPD52L1	ABL2
Description		TPD52 like 1	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Manganese Ion Binding Metal Ion Binding Actin Filament Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MAP Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Apoptotic Signaling Pathway	Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Protein Modification Process Cellular Response To Retinoic Acid Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Cell Motility Positive Regulation Of T Cell Migration
Pathways		Golgi Associated Vesicle Biogenesis	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3
Drugs			ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)	IgE grass sensitization ( 22036096)
Interacting Genes		15 interacting genes: ABL2 DAPK1 EIF3J GPR135 HDAC1 MAL2 MAP3K5 PAK6 PBX3 TPD52 TPD52L2 TPD52L3 YAE1 YWHAB YWHAZ	34 interacting genes: ABL1 AR BCR CAT COXFA4L3 CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		7164	27
HPRD ID		07236	01259
Ensembl ID		ENSG00000111907	ENSG00000143322
Uniprot IDs		E9PPQ1 J3KNE7 Q16890	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Cytoplasm Protein Kinase Activity Cellular Response To Oxidative Stress DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Protein Domain Specific Binding Cellular Response To Starvation Response To Starvation Posterior Compartment Specification Anterior Compartment Pattern Formation Negative Regulation Of Protein Localization To Nucleus Protein Sequestering Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Phosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Population Proliferation Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Migration Basal Plasma Membrane Transferase Activity Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Biological Quality Regulation Of Cell Motility Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion
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