DNAJB9 and GRIK1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DNAJB9	GRIK1
Description		DnaJ heat shock protein family (Hsp40) member B9	glutamate ionotropic receptor kainate type subunit 1
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Extracellular Exosome	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Protein Binding Hsp70 Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Positive Regulation Of Immunoglobulin Production Response To Unfolded Protein B Cell Differentiation Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		XBP1(S) activates chaperone genes	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate Tezampanel
Diseases
GWAS		Body size at age 10 ( 32376654) Metabolite levels ( 23823483) Smoking behavior ( 22006218)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		11 interacting genes: DYNLL1 ECPAS FSCN1 GARIN6 GRIK1 MYL6 PLK1 RFK SLC16A8 TCEA2 TCERG1	31 interacting genes: COPS5 CYSLTR2 DLG4 DLST DNAJB9 FLNA GORASP2 GRIK2 GRIK3 GRIK4 GRIK5 GRIP1 HOMER1 HSP90B1 KALRN KCNQ2 LDB2 PICK1 PTPRD RANBP9 RNF123 SDCBP SEPTIN7 SIPA1L3 SNAPIN SRI ST13 TAAR1 UBE2O ZFC3H1 ZNF592
Entrez ID		4189	2897
HPRD ID		07047	00693
Ensembl ID		ENSG00000128590	ENSG00000171189
Uniprot IDs		Q6FIF1 Q9UBS3	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs		2CTR	2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?			Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Cell Communication Regulation Of Signaling Synapse Cell-cell Signaling Signaling Cell Communication Modulation Of Chemical Synaptic Transmission Presynaptic Membrane Regulation Of Presynaptic Membrane Potential Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Hippocampal Mossy Fiber To CA3 Synapse Receptor Clustering Postsynaptic Membrane Localization Within Membrane Postsynaptic Density Monoatomic Ion Channel Activity Regulation Of Membrane Potential Dendrite Cytoplasm Protein Localization To Membrane Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission Glutamatergic Synapse Protein Sequestering Activity Plasma Membrane Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Synaptic Vesicle Negative Regulation Of Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Regulation Of Signal Transduction Perikaryon Glutamate Receptor Activity Protein-containing Complex Localization Cellular Localization Regulation Of Neuron Projection Arborization Regulation Of Synaptic Transmission, Glutamatergic
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