DNAJB9 and RFK

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DNAJB9	RFK
Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 9	riboflavin kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Misfolded Protein Binding	ATP Binding Riboflavin Kinase Activity Metal Ion Binding
	Biological Process	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Apoptotic Process Riboflavin Biosynthetic Process FMN Biosynthetic Process Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs			Riboflavin Riboflavin Monophosphate Adenosine-5\'-Diphosphate
Diseases
GWAS		Smoking behavior ( 22006218)	Multiple sclerosis (age of onset) ( 19010793)
Protein-Protein Interactions		10 interactors: DYNLL1 FAM71C FSCN1 KIAA0368 MYL6 PLK1 RFK SLC16A8 TCEA2 TCERG1	2 interactors: DNAJB9 RAB1A
Entrez ID		4189	55312
HPRD ID		07047	17969
Ensembl ID		ENSG00000128590	ENSG00000135002
Uniprot IDs		Q6FIF1 Q9UBS3	B2RDZ2 Q969G6
PDB IDs		2CTR	1NB0 1NB9 1P4M 1Q9S
Enriched GO Terms of Interacting Partners?		Riboflavin Biosynthetic Process FMN Biosynthetic Process Activation Of APC-Cdc20 Complex Activity G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of NAD(P)H Oxidase Activity	Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Interleukin-8 Production Cargo Loading Into Vesicle Growth Hormone Secretion Positive Regulation Of Glycoprotein Metabolic Process COPII-coated Vesicle Budding Virion Assembly Positive Regulation Of Protein Metabolic Process Cytokine Secretion Vesicle Transport Along Microtubule Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization ER-associated Ubiquitin-dependent Protein Catabolic Process Localization Within Membrane Melanosome Localization Autophagic Vacuole Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Organelle Transport Along Microtubule Macroautophagy Rab Protein Signal Transduction Cellular Pigmentation Peptide Hormone Secretion Peptide Secretion Catabolic Process Golgi Organization Membrane Budding Hormone Secretion Endoplasmic Reticulum Unfolded Protein Response Hormone Transport Peptide Transport Cellular Response To Unfolded Protein ER To Golgi Vesicle-mediated Transport Regulation Of Protein Metabolic Process Vacuole Organization ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Pigmentation Protein Secretion Amide Transport Response To Unfolded Protein Microtubule-based Transport Cytokine Production Cellular Response To Starvation Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		applicable attractor bcam biomarker bionetworks calculating called cd68 consideration cxcl12 dream existing facility fgd3 hormonal lym mes metagene metagenes outperform predictions remarkable sage selector suggestion susd3 unexpected universally winning	alter analytical associations biologically depressive electrophoretic example genomics goal grk5 gwa insights joining mobility plausible reached relevance remission reuptake riboflavin rs11144870 rs915120 serotonin shift snp snps ssri ssris wide
Tagcloud (Difference) ?		applicable attractor bcam biomarker bionetworks calculating called cd68 consideration cxcl12 dream existing facility fgd3 hormonal lym mes metagene metagenes outperform predictions remarkable sage selector suggestion susd3 unexpected universally winning	alter analytical associations biologically depressive electrophoretic example genomics goal grk5 gwa insights joining mobility plausible reached relevance remission reuptake riboflavin rs11144870 rs915120 serotonin shift snp snps ssri ssris wide
Tagcloud (Intersection) ?