P2RX4 and NBPF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P2RX4	NBPF19
Description		purinergic receptor P2X 4	NBPF member 19
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse	Cytoplasm
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Monoatomic Ion Transport Response To Stress Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metal Ion Transport Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Cell Migration Positive Regulation Of Prostaglandin Secretion Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Regulation Of Ruffle Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection
Drugs		Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)	Serum uric acid levels ( 30993211)
Interacting Genes		9 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA WNT4	229 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GARIN6 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IGSF8 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR19 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZFTRAF1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837
Entrez ID		5025	101060226
HPRD ID		09017
Ensembl ID		ENSG00000135124	ENSG00000271383
Uniprot IDs		Q99571	A0A087WUL8
PDB IDs		9BQH 9BQI 9C48
Enriched GO Terms of Interacting Partners?		Intermediate Filament Mitotic DNA Replication Initiation Positive Regulation Of Translational Elongation Nuclear Division Positive Regulation Of Ribosome Biogenesis Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Renal Vesicle Induction Nephron Morphogenesis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Dermatome Development Negative Regulation Of Male Gonad Development Renal Vesicle Formation Somatotropin Secreting Cell Differentiation Female Sex Determination Paramesonephric Duct Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Metanephric Nephron Development Keratin Filament Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Positive Regulation Of Cellular Component Biogenesis Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Pericyte Cell Differentiation Immature T Cell Proliferation In Thymus Blood Vessel Maturation Fibrinogen Binding Regulation Of Cortisol Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Testosterone Biosynthetic Process Histone Binding	Intermediate Filament Keratin Filament Protein Binding Keratinization Epidermis Development Hair Cycle Tissue Development Nitric Oxide Transport Carbon Dioxide Transport
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