P2RX4 and KRTAP1-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P2RX4	KRTAP1-1
Description		purinergic receptor P2X 4	keratin associated protein 1-1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity	Protein Binding
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Monoatomic Ion Transport Response To Stress Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metal Ion Transport Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Cell Migration Positive Regulation Of Prostaglandin Secretion Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Regulation Of Ruffle Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection	Keratinization
Drugs		Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		9 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA WNT4	218 interacting genes: ADAM12 ADAMTSL3 ADAMTSL4 AGXT AKR7A3 ALDH3B1 ALPP AQP1 ASPSCR1 ATG9A BCAM C10orf62 C11orf87 C19orf38 CAMK2B CATIP CATSPER1 CD300LG CERK CHIC2 CHRD CHRNG CLDN2 CNNM3 CREB5 CRH CRY2 CSF1 CST2 CTRC CTSZ CYSLTR2 CYSRT1 DHRS1 DMRT3 DOCK2 DRD5 EFNA3 EMC7 FAM221A FAM76B FAM90A1 FARS2 FBXW5 FEZF1 FKBP1B FOXD4L3 FRS3 FZD10 GARIN6 GLP1R GLYAT GNE GRN GSTP1 GUCD1 HCK HEY2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HSBP1 HSPA12B HYAL2 IFITM2 IGSF8 IL16 INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KRT20 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LRFN4 LRRN4 MAGOHB MAPKBP1 MELTF MGAT5B MRGBP MRPL23 MT1B MXD3 MXI1 MYOM1 NECTIN2 NECTIN3 NMU NPDC1 NR1D2 NTM NUBP2 NUFIP2 OLFM2 OLIG3 OR14I1 OTX1 P2RX4 P2RY6 PCSK5 PDE9A PGAP6 PHLDA1 POU4F2 PRF1 PRKAB2 PRKAG1 PRPF31 PSMA1 PTK7 PTPMT1 PVR QPRT R3HDM2 RASD1 REM2 RNF111 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCARF1 SCNM1 SDC3 SEMA3B SHFL SLC23A1 SLC43A2 SLC68A1 SLC6A20 SLC7A11 SLIT1 SMARCE1 SMCP SMOC1 SNAI1 SNX18 SPACA9 SPRY1 STK16 TAPBPL TCEANC TFAP2D TGFB1 TLE5 TNP2 TSFM VASN VGLL3 VSTM4 WNT11 ZBTB48 ZBTB9 ZDHHC1 ZFTRAF1 ZNF124 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF491 ZNF497 ZNF524 ZNF581 ZNF587 ZNF648 ZNF669 ZNF696 ZNF786 ZNF837
Entrez ID		5025	81851
HPRD ID		09017	12304
Ensembl ID		ENSG00000135124	ENSG00000188581
Uniprot IDs		Q99571	Q07627
PDB IDs		9BQH 9BQI 9C48
Enriched GO Terms of Interacting Partners?		Intermediate Filament Mitotic DNA Replication Initiation Positive Regulation Of Translational Elongation Nuclear Division Positive Regulation Of Ribosome Biogenesis Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Renal Vesicle Induction Nephron Morphogenesis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Dermatome Development Negative Regulation Of Male Gonad Development Renal Vesicle Formation Somatotropin Secreting Cell Differentiation Female Sex Determination Paramesonephric Duct Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Metanephric Nephron Development Keratin Filament Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Positive Regulation Of Cellular Component Biogenesis Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Pericyte Cell Differentiation Immature T Cell Proliferation In Thymus Blood Vessel Maturation Fibrinogen Binding Regulation Of Cortisol Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Testosterone Biosynthetic Process Histone Binding	Protein Binding Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Susceptibility To T Cell Mediated Cytotoxicity
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