P2RX4 and CDH5

Number of citations of the paper that reports this interaction (PMID 12088286)
8

Data Source:
HPRD (in vivo)

		P2RX4	CDH5
Gene Name		purinergic receptor P2X, ligand gated ion channel, 4	cadherin 5, type 2 (vascular endothelium)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Neuronal Cell Body Terminal Bouton Dendritic Spine Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding ATP Binding Drug Binding Zinc Ion Binding Protein Homodimerization Activity Cadherin Binding	Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Ion Channel Binding
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Nitric Oxide Biosynthetic Process Transport Calcium Ion Transport Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Neuronal Action Potential Sensory Perception Of Pain Positive Regulation Of Prostaglandin Secretion Response To ATP Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Vasodilation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Protein Homooligomerization Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To ATP Apoptotic Signaling Pathway Cation Transmembrane Transport	Blood Vessel Maturation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Proliferation Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways			Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CDH5 KRTAP5-9 MCM2 NOTCH2NL PIH1D3 WNT4	20 interactors: CSK CTNNA1 CTNNB1 CTNND1 DSP EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		5025	1003
HPRD ID		09017	03075
Ensembl ID		ENSG00000135124	ENSG00000179776
Uniprot IDs		E7EPF7 F6RU17 Q5U089 Q99571	P33151
PDB IDs
Enriched GO Terms of Interacting Partners?		Immature T Cell Proliferation In Thymus Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Male Gonad Development Positive Regulation Of Aldosterone Biosynthetic Process Female Sex Determination Regulation Of Testosterone Biosynthetic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Dermatome Development Thyroid-stimulating Hormone-secreting Cell Differentiation Renal Vesicle Induction Paramesonephric Duct Development Somatotropin Secreting Cell Differentiation Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Non-canonical Wnt Signaling Pathway Via MAPK Cascade Neuroendocrine Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Mammary Gland Branching Involved In Pregnancy Renal Vesicle Formation Blood Vessel Maturation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process DNA Unwinding Involved In DNA Replication Positive Regulation Of Hormone Biosynthetic Process Regulation Of Glucocorticoid Metabolic Process Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Adenohypophysis Development Axonemal Dynein Complex Assembly Renal Vesicle Morphogenesis Androgen Biosynthetic Process Mesenchymal To Epithelial Transition Positive Regulation Of Meiotic Nuclear Division Metanephric Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Metanephric Nephron Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Cellular Response To Epidermal Growth Factor Stimulus Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Collagen Metabolic Process DNA Strand Elongation Involved In DNA Replication	Cell-cell Junction Organization Adherens Junction Organization Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Indole-3-methanol Cell Junction Assembly Regulation Of ERK1 And ERK2 Cascade Cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Response To Stimulus Regulation Of Signal Transduction Response To Wounding Positive Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Cell Migration Cell Motility Wound Healing Response To Growth Factor Regulation Of Intracellular Signal Transduction Platelet Activation Organ Development Cellular Response To Organic Substance Cellular Component Assembly Cell Activation Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Organic Substance Movement Of Cell Or Subcellular Component Cell-cell Junction Assembly Protein Heterooligomerization Negative Regulation Of Signaling Regulation Of Protein Localization System Development Peptidyl-tyrosine Phosphorylation Response To Stress Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation
Tagcloud ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	1beta bioreactor cd11b constructs dataset dioxepan dxo engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?		ec ecs