MARK1 and TAOK1

Number of citations of the paper that reports this interaction (PMID 14976552)
271

Data Source:
HPRD (in vitro)

		MARK1	TAOK1
Gene Name		MAP/microtubule affinity-regulating kinase 1	TAO kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau-protein Kinase Activity Phosphatidic Acid Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Neuron Migration Protein Phosphorylation Cytoskeleton Organization Wnt Signaling Pathway Intracellular Signal Transduction	MAPK Cascade Activation Of MAPKK Activity Mitotic Cell Cycle DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus G2 DNA Damage Checkpoint Spindle Checkpoint Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cytoskeleton Organization Execution Phase Of Apoptosis
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Bipolar disorder ( 22205951) Fat distribution (HIV) ( 21897333)	Mean platelet volume ( 22139419 19110211 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		7 interactors: CCDC102B GJA5 MAP2 MAP4 MAPT STK11 TAOK1	7 interactors: C8orf33 CSNK1E DYNC1I1 GEMIN7 MAP2K3 MARK1 WT1
Entrez ID		4139	57551
HPRD ID		07353	15467
Ensembl ID		ENSG00000116141	ENSG00000160551
Uniprot IDs		B4DIB3 Q9P0L2	Q7L7X3
PDB IDs		2HAK 3OSE
Enriched GO Terms of Interacting Partners?		Organelle Localization Microtubule Cytoskeleton Organization Execution Phase Of Apoptosis Positive Regulation Of Axonogenesis Axonogenesis Vasomotion Microtubule Sliding AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling TCR Signalosome Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Cell Polarity Neuron Projection Morphogenesis Atrial Ventricular Junction Remodeling Pulmonary Valve Formation Foramen Ovale Closure Positive Regulation Of Cell Communication By Chemical Coupling Cell Morphogenesis Involved In Differentiation Microtubule-based Process Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Establishment Or Maintenance Of Cell Polarity Cell Part Morphogenesis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Chemical Coupling Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Neuron Development Apoptotic Process Positive Regulation Of Neuron Projection Development Anatomical Structure Morphogenesis Programmed Cell Death Negative Regulation Of Glomerular Filtration Cell Cycle Process Cell Death Death Cell Morphogenesis Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Mitral Valve Development SA Node Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Anoikis Cellular Response To UV-B Regulation Of Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Neuron Differentiation Cytoskeleton Organization Activation Of Protein Kinase Activity	Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Adrenal Cortex Formation Negative Regulation Of Glomerulus Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Zygotic Determination Of Anterior/posterior Axis, Embryo Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Female Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric S-shaped Body Morphogenesis Regulation Of Glomerular Mesangial Cell Proliferation Wnt Signaling Pathway S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Diaphragm Development Protein Phosphorylation RNA Splicing Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development Seminiferous Tubule Development Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Movement Of Cell Or Subcellular Component Muscle Cell Fate Commitment Mesenchymal To Epithelial Transition Metanephric Mesenchyme Development Sertoli Cell Development Anterior/posterior Axis Specification, Embryo Sex Determination Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis
Tagcloud ?		backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning	adamts16 ambiguous biopsies capacities cen17 cish commercially concordance copy deserves diploidy embedded expensive fish french gold ish lap3 mks1 mrm1 paraffin participating polysomy primer qpcr sish sstr2 tsn utp6
Tagcloud (Difference) ?		backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning	adamts16 ambiguous biopsies capacities cen17 cish commercially concordance copy deserves diploidy embedded expensive fish french gold ish lap3 mks1 mrm1 paraffin participating polysomy primer qpcr sish sstr2 tsn utp6
Tagcloud (Intersection) ?