HLA-DRB4 and MAGEA6

Number of citations of the paper that reports this interaction (PubMedID 12631591)
0

Data Source:
BioGRID (unspecified method)

		HLA-DRB4	MAGEA6
Description		major histocompatibility complex, class II, DR beta 4	MAGE family member A6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus
	Molecular Function	MHC Class II Protein Complex Binding Peptide Antigen Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule
Diseases
GWAS			Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		3 interacting genes: ASMTL CTAG1B MAGEA6	75 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76
Entrez ID		3126	4105
HPRD ID		09986	02168
Ensembl ID			ENSG00000197172
Uniprot IDs		P13762 X5D2U9	P43360
PDB IDs
Enriched GO Terms of Interacting Partners?		DTTP Diphosphatase Activity UTP Diphosphatase Activity O-methyltransferase Activity Nucleoside Triphosphate Diphosphatase Activity TRNA Threonylcarbamoyladenosine Metabolic Process	Protein Binding SNARE Complex Suppression Of Viral Release By Host
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