MAF and MAFA

Number of citations of the paper that reports this interaction (PubMedID 12011435)
36

Data Source:
HPRD (in vitro)

		MAF	MAFA
Description		MAF bZIP transcription factor	MAF bZIP transcription factor A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Insulin Secretion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX2 regulates osteoblast differentiation	Regulation of gene expression in beta cells
Drugs
Diseases		Multiple myeloma
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Colorectal cancer ( 31826910 30529582) Depressive symptoms (SSRI exposure interaction) ( 25649181) Estimated glomerular filtration rate ( 31015462) Height ( 20668459) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lysophosphatidylcholine levels ( 31551469) Macular thickness ( 30535121) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602 21833088 31604244) Obesity ( 19151714) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Refractive error ( 32231278) Renal function-related traits (urate) ( 22797727) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 29403010 33547301 33339817) Serum thyroid-stimulating hormone levels ( 24852370) Serum uric acid levels ( 30993211) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293) Triglyceride levels ( 32203549) Urate levels ( 31985003 23263486) Vitamin C levels ( 33203707)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2	6 interacting genes: HERC4 MAF MAPK1 MAPK14 NEUROD1 PDX1
Entrez ID		4094	389692
HPRD ID		01518	14346
Ensembl ID		ENSG00000178573	ENSG00000182759
Uniprot IDs		H3BP11 O75444	Q8NHW3
PDB IDs			4EOT
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels	Transcription By RNA Polymerase II Negative Regulation Of Type B Pancreatic Cell Apoptotic Process DNA-templated Transcription Cell Differentiation Response To Nutrient Levels Enteroendocrine Cell Differentiation MAP Kinase Activity Endocrine Pancreas Development Cellular Developmental Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Transport Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Epithelial Cell Apoptotic Process Inner Ear Development Epithelial Cell Differentiation Peptide Hormone Secretion Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Acadesine Embryonic Morphogenesis Sequence-specific DNA Binding Positive Regulation Of Insulin Secretion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Peptide Secretion Regulation Of Ossification Regulation Of Cellular Localization Stem Cell Differentiation Animal Organ Development Homeostatic Process Regulation Of Establishment Of Protein Localization Anatomical Structure Morphogenesis Ficolin-1-rich Granule Lumen Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Response To Peptide Response To Tumor Necrosis Factor RNA Metabolic Process Macromolecule Metabolic Process
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