MAF and USF2

Number of citations: 0 (PubMedID 9070273)
Data Source: HPRD (in vitro, in vivo)

		MAF	USF2
Name		MAF bZIP transcription factor	upstream transcription factor 2, c-fos interacting
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By RNA Polymerase II Lactation Glucose Mediated Signaling Pathway Late Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		RUNX2 regulates osteoblast differentiation	Estrogen-dependent gene expression
Diseases		Multiple myeloma	None
GWAS		Alanine aminotransferase levels ( 34315874 33547301 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Colorectal cancer ( 31826910 30529582 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 20668459 ) High density lipoprotein cholesterol levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lysophosphatidylcholine levels ( 31551469 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 24076602 21833088 31604244 ) Obesity ( 19151714 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Refractive error ( 32231278 ) Renal function-related traits (urate) ( 22797727 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Serum alkaline phosphatase levels ( 29403010 33547301 33339817 ) Serum thyroid-stimulating hormone levels ( 24852370 ) Serum uric acid levels ( 30993211 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Thyroid volume ( 21565293 ) Triglyceride levels ( 32203549 ) Urate levels ( 31985003 23263486 ) Vitamin C levels ( 33203707 )	Adverse response to drug ( 30420678 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )
Novel Interactors		1 novel interactors: NEU1	1 novel interactors: ICAM3
Interacting Genes		16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2	10 interacting genes: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A RELA TEAD2 USF1
Entrez ID		4094	7392
HPRD ID		01518	02668
Ensembl ID		ENSG00000178573	ENSG00000105698
Uniprot IDs		H3BP11 O75444	Q15853
PDB IDs		Not available	8IA3
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Response To Nutrient Levels Nucleobase-containing Compound Biosynthetic Process DNA Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Nucleic Acid Metabolic Process Transcription Coactivator Binding Response To Radiation RNA Metabolic Process Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Light Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Glucose Metabolic Process Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Nutrient Response To UV DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Muscle Stretch Hexose Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production