MAF and MAFG

Number of citations: 0 (PubMedID 12149651)
Data Source: HPRD (in vitro)

		MAF	MAFG
Name		MAF bZIP transcription factor	MAF bZIP transcription factor G
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Adult Behavior Regulation Of Cell Population Proliferation Regulation Of Epidermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX2 regulates osteoblast differentiation	Nuclear events mediated by NFE2L2 NFE2L2 regulates pentose phosphate pathway genes Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Diseases		Multiple myeloma	None
GWAS		Alanine aminotransferase levels ( 34315874 33547301 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Colorectal cancer ( 31826910 30529582 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 20668459 ) High density lipoprotein cholesterol levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lysophosphatidylcholine levels ( 31551469 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 24076602 21833088 31604244 ) Obesity ( 19151714 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Refractive error ( 32231278 ) Renal function-related traits (urate) ( 22797727 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Serum alkaline phosphatase levels ( 29403010 33547301 33339817 ) Serum thyroid-stimulating hormone levels ( 24852370 ) Serum uric acid levels ( 30993211 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Thyroid volume ( 21565293 ) Triglyceride levels ( 32203549 ) Urate levels ( 31985003 23263486 ) Vitamin C levels ( 33203707 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2	24 interacting genes: ATF3 BATF3 CHD3 CREBBP CYP2E1 DDIT3 GTF2A1L HIF1A HOMEZ HOXD12 MAF MAPK3 MED31 NFE2 NFE2L1 NFE2L2 NFIL3 PAX6 PIDD1 PPP1CA PRRX1 RBM48 SNRPN VIM
Entrez ID		4094	4097
HPRD ID		01518	03605
Ensembl ID		ENSG00000178573	ENSG00000197063
Uniprot IDs		H3BP11 O75444	O15525
PDB IDs		Not available	7X5E 7X5F 7X5G
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels	Chromatin RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Integrated Stress Response Signaling DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Nucleoplasm Regulation Of Metabolic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific CHOP-ATF3 Complex Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Astrocyte Differentiation Negative Regulation Of Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Cell Redox Homeostasis