NTSR1

Description		neurotensin receptor 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Symmetric Synapse Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Neuron Spine Membrane Raft
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Neurotensin Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Temperature Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization CAMP Biosynthetic Process Response To Stress Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Learning Associative Learning Adult Locomotory Behavior Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Response To Food Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Lipid Positive Regulation Of Locomotion Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Respiratory Gaseous Exchange Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Inositol Phosphate Biosynthetic Process D-aspartate Import Across Plasma Membrane Inositol Phosphate Catabolic Process Vocalization Behavior Positive Regulation Of Arachidonate Secretion Positive Regulation Of Inhibitory Postsynaptic Potential L-glutamate Import Across Plasma Membrane Conditioned Place Preference Regulation Of Behavioral Fear Response
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Metabolite levels ( 23823483)
Novel Interacting Genes		1 novel interacting genes: TRAF6
Interacting Genes		2 interacting genes: ARRB2 NTS
Entrez ID		4923
HPRD ID		01218
Ensembl ID		ENSG00000101188
Uniprot IDs		P30989
PDB IDs		2LYW 6OS9 6OSA 6PWC 6UP7 7UL2 8JPB 8JPC 8JPF
Enriched GO Terms of Interacting Partners?		Protein Kinase B Binding Regulation Of Interleukin-12 Production Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Angiotensin Receptor Binding Regulation Of Interleukin-6 Production Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Lymphocyte Mediated Immunity Neuropeptide Receptor Binding Protein-macromolecule Adaptor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Post-translational Protein Modification Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication D1 Dopamine Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Interleukin-17A-mediated Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic Interleukin-33-mediated Signaling Pathway DNA-templated Transcription Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway G Protein-coupled Receptor Internalization Negative Regulation Of Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cardiocyte Differentiation MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity
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