MIR214 and PUM2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR214	PUM2
Description		microRNA 214	pumilio RNA binding family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus RISC Complex Perinuclear Region Of Cytoplasm Extracellular Vesicle	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Chemokine Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Necroptotic Process Cellular Response To Hypoxia Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Connective Tissue Replacement	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Neddylation
Drugs
Diseases
GWAS		Height ( 31562340)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		92 interacting genes: AIMP1 AIMP2 AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 DARS1 DDX1 DDX21 DDX23 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PTBP1 PTCD3 PUF60 PUM1 PUM2 QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZFR ZNF346	25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1
Entrez ID		406996	23369
HPRD ID			09527
Ensembl ID		ENSG00000283844	ENSG00000055917
Uniprot IDs			B7ZL34 Q8TB72
PDB IDs			3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Macromolecule Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome Nucleoplasm Nucleus Spliceosomal Complex Cytoplasmic Stress Granule Regulation Of MRNA Processing MiRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleolus TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Helicase Activity Negative Regulation Of Translation Positive Regulation Of Cytoplasmic Translation RNA Transport Positive Regulation Of Gene Expression Ligase Activity CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization
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