MIR205 and PGAM5

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR205	PGAM5
Description		microRNA 205	PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Fibroblast Growth Factor Production Regulation Of Aorta Morphogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production	Programmed Cell Death Macroautophagy Necroptotic Process Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		92 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CELF1 CELF2 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PGAM5 PLRG1 PTBP1 PTBP3 PTCD3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM45 RBMS1 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H7B ZNF346	32 interacting genes: HSPA1B MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR141 MIR145 MIR15A MIR16-1 MIR18B MIR200B MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR34A MIR451A MIR93 MIRLET7A1 MIRLET7A2 MIRLET7B MIRLET7E MIRLET7F1 RNF5 SETDB1 UBE4B XIAP YWHAG ZBTB16
Entrez ID		406988	192111
HPRD ID			14681
Ensembl ID		ENSG00000284485	ENSG00000247077
Uniprot IDs			A0A994J4Y8 Q96HS1
PDB IDs			3MXO 3O0T 5MUF 6CNI 6CNL 7QAL 7QAM 7QAO 7QAP 8IN0
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleus Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression Cytoplasmic Stress Granule Spliceosomal Complex MRNA 3'-UTR Binding Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding Regulation Of Translation Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Catabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Ligase Activity MRNA Stabilization Regulation Of RNA Stability Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Primary Metabolic Process	MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of MRNA Stability Negative Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process
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