PGAM5 and MIR200B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PGAM5	MIR200B
Description		PGAM family member 5, mitochondrial serine/threonine protein phosphatase	microRNA 200b
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	RISC Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Programmed Cell Death Macroautophagy Necroptotic Process Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cold-induced Thermogenesis	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Vascular Wound Healing Negative Regulation Of Interleukin-33 Production Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		32 interacting genes: HSPA1B MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR141 MIR145 MIR15A MIR16-1 MIR18B MIR200B MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR34A MIR451A MIR93 MIRLET7A1 MIRLET7A2 MIRLET7B MIRLET7E MIRLET7F1 RNF5 SETDB1 UBE4B XIAP YWHAG ZBTB16	83 interacting genes: ADARB1 APOBEC3B AQR C1QBP CDC5L CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PTCD3 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		192111	406984
HPRD ID		14681
Ensembl ID		ENSG00000247077	ENSG00000207730
Uniprot IDs		A0A994J4Y8 Q96HS1
PDB IDs		3MXO 3O0T 5MUF 6CNI 6CNL 7QAL 7QAM 7QAO 7QAP 8IN0
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of MRNA Stability Negative Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression Nucleus Regulation Of Translation MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization MRNA Stabilization Nucleolus Negative Regulation Of Translation TRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Gene Expression Regulation Of RNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity P-body CRD-mediated MRNA Stabilization TRNA Aminoacylation
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