PGAM5 and RNF5

Number of citations of the paper that reports this interaction (PubMedID 34735734)
46

Data Source:
BioGRID (pull down)

		PGAM5	RNF5
Description		PGAM family member 5, mitochondrial serine/threonine protein phosphatase	ring finger protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Programmed Cell Death Macroautophagy Necroptotic Process Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cold-induced Thermogenesis	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Protein Destabilization ERAD Pathway Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways			ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		32 interacting genes: HSPA1B MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR141 MIR145 MIR15A MIR16-1 MIR18B MIR200B MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR34A MIR451A MIR93 MIRLET7A1 MIRLET7A2 MIRLET7B MIRLET7E MIRLET7F1 RNF5 SETDB1 UBE4B XIAP YWHAG ZBTB16	54 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 EPHA2 EPHA3 EPHA4 FAM241B FHOD1 GLP1R INSIG2 JKAMP JMJD6 LEPROTL1 MPDZ MS4A1 ORMDL3 PGAM5 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4
Entrez ID		192111	6048
HPRD ID		14681	04057
Ensembl ID		ENSG00000247077	ENSG00000204308
Uniprot IDs		A0A994J4Y8 Q96HS1	A0A024RCQ4 Q99942
PDB IDs		3MXO 3O0T 5MUF 6CNI 6CNL 7QAL 7QAM 7QAO 7QAP 8IN0
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of MRNA Stability Negative Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination ATP Binding Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Binding Proteolysis Nucleotide Binding Protein K63-linked Ubiquitination Protein Metabolic Process Fasciculation Of Motor Neuron Axon Ephrin Receptor Activity Catabolic Process Membrane Positive Regulation Of Protein Polyubiquitination Fasciculation Of Sensory Neuron Axon UBC13-MMS2 Complex ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Cellular Response To Stress Endoplasmic Reticulum Membrane Regulation Of Protein Polyubiquitination Endosome Proteasomal Protein Catabolic Process ISG15-protein Conjugation Cholesterol Biosynthetic Process GPI-linked Ephrin Receptor Activity Positive Regulation Of Protein K63-linked Ubiquitination Golgi Trans Cisterna Sterol Biosynthetic Process Golgi Medial Cisterna Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Stress Fiber Assembly Protein Catabolic Process Endoplasmic Reticulum Regulation Of Protein K63-linked Ubiquitination
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