MIR145 and YBX1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR145	YBX1
Description		microRNA 145	Y-box binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex Extracellular Exosome	P-body Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Stress Granule Synapse Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Reader Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Ectodermal Cell Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Fibroblast Migration Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-10 Production Regulation Of Collagen Biosynthetic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Vascular Associated Smooth Muscle Cell Differentiation Myofibroblast Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Macrophage Activation Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Positive Regulation Of Macrophage Differentiation Mesodermal Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Aorta Smooth Muscle Tissue Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Positive Regulation Of Cellular Response To Hypoxia Regulation Of Phenotypic Switching Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Somatic Stem Cell Population Maintenance Negative Regulation Of Somatic Stem Cell Division Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Cellular Senescence
Pathways			SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3
Drugs
Diseases
GWAS
Interacting Genes		80 interacting genes: ADARB1 AGO2 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NONO NUDT16L1 NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346	125 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CEBPA CSNK2A1 CTCF DANCR DUX4 FBXO33 FMR1 FUS GSK3B HABP4 HLA-C HNRNPD HNRNPK HOXC-AS3 IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NEIL3 NFYB OGT PCBP2 PCNA PFKFB4 PRPF40A PURA RBBP6 RNF10 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA VPS35 WEE2-AS1 ZBTB7A
Entrez ID		406937	4904
HPRD ID			01095
Ensembl ID		ENSG00000276365	ENSG00000065978
Uniprot IDs			P67809
PDB IDs			1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Regulation Of RNA Splicing Nucleus Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Nucleoplasm Macromolecule Metabolic Process MiRNA Binding Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Gene Expression RNA Stabilization Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Stability MRNA 5'-UTR Binding Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process U2 SnRNP Double-stranded RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Translation	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Regulation Of Metabolic Process Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Developmental Process Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Protein Metabolic Process
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