MIR145 and NUDT16L1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR145	NUDT16L1
Description		microRNA 145	nudix hydrolase 16 like 1
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex Extracellular Exosome	Nucleus
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Binding Protein Binding SnoRNA Binding Protein Homodimerization Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Regulation Of Smooth Muscle Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Ectodermal Cell Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Fibroblast Migration Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-10 Production Regulation Of Collagen Biosynthetic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Vascular Associated Smooth Muscle Cell Differentiation Myofibroblast Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Macrophage Activation Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Positive Regulation Of Macrophage Differentiation Mesodermal Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Aorta Smooth Muscle Tissue Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Positive Regulation Of Cellular Response To Hypoxia Regulation Of Phenotypic Switching Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Somatic Stem Cell Population Maintenance Negative Regulation Of Somatic Stem Cell Division Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation	MRNA Catabolic Process Sno(s)RNA Catabolic Process Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS
Interacting Genes		80 interacting genes: ADARB1 AGO2 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NONO NUDT16L1 NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346	52 interacting genes: APP CABP2 CEBPA ERBB2 FBXO7 HNRNPF HNRNPH1 IKZF3 INCA1 KRT31 LRRK1 METTL17 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR18B MIR200C MIR21 MIR25 MIR31 MIR34A MIR34B MIR363 MIR451A MIR7-3 MIR9-1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4L NEK6 NTAQ1 PNMA1 RECK SMARCD1 TRAF2 TRAF4 TRIM68 ZRANB1
Entrez ID		406937	84309
HPRD ID			15309
Ensembl ID		ENSG00000276365	ENSG00000168101
Uniprot IDs			B2RD96 K7ENA3 Q9BRJ7 W4VSQ8
PDB IDs			3KVH 5ZCJ 6CO1 6D0L 8U3S
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Regulation Of RNA Splicing Nucleus Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Nucleoplasm Macromolecule Metabolic Process MiRNA Binding Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Gene Expression RNA Stabilization Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Stability MRNA 5'-UTR Binding Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process U2 SnRNP Double-stranded RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Translation	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Biosynthetic Process RNA Destabilization Negative Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Angiogenesis Regulation Of Vasculature Development Extracellular Space Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus
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