CD180 and SELENOS

Data Source: HiPPIP (Novel)

		CD180	SELENOS
Name		CD180 molecule	selenoprotein S
Structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Membrane Mitotic Spindle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex
	Molecular Function	Lipopolysaccharide Immune Receptor Activity Protein Binding Signaling Receptor Activity	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	B Cell Proliferation Involved In Immune Response Immune System Process Inflammatory Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation Innate Immune Response Cellular Response To Lipopolysaccharide	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis Intracellular Protein Transport ER Overload Response Response To Glucose Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress ERAD Pathway Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Toll Like Receptor 4 (TLR4) Cascade	E3 ubiquitin ligases ubiquitinate target proteins
GWAS		Common carotid intima-media thickness in HIV infection ( 29206233 ) General cognitive ability ( 29844566 ) Gut microbiota (bacterial taxa) ( 27723756 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: ADAMTS6 SELENOS	16 novel interactors: BLZF1 CD180 CELF4 EIF2AK1 ETV7 LIMK1 LINS1 LRRK1 NCBP1 OR4F4 SNRPA1 SYNM TARS3 TM2D3 TTC23 ZBTB33
Interacting Genes		1 interacting genes: LY86	9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP
Entrez ID		4064	55829
HPRD ID		03749	12133
Ensembl ID		ENSG00000134061	ENSG00000131871
Uniprot IDs		Q99467	Q6GYA4 Q9BQE4
PDB IDs		3B2D	2Q2F 5KIU 5KIY 6DO4
GO Terms Enriched among Interactors		Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER Overload Response Very-low-density Lipoprotein Particle Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of Glycogen Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Acute Inflammatory Response To Antigenic Stimulus Ubiquitin-specific Protease Binding Derlin-1 Retrotranslocation Complex Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Myeloid Cell Apoptotic Process Derlin-1-VIMP Complex Response To Redox State Regulation Of Lipopolysaccharide-mediated Signaling Pathway Aorta Development Coronary Vasculature Development Protein Exit From Endoplasmic Reticulum Regulation Of Myeloid Cell Apoptotic Process Antioxidant Activity Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipopolysaccharide-mediated Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Glycogen Metabolic Process Artery Development Cardiac Septum Development Cell Redox Homeostasis Regulation Of Acute Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Gluconeogenesis	Ubiquitin Protein Ligase Binding Spliceosomal Complex Assembly Derlin-1 Retrotranslocation Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Protein-RNA Complex Assembly Retrograde Protein Transport, ER To Cytosol MHC Class I Protein Binding Ubiquitin-specific Protease Binding High-density Lipoprotein Particle Regulation Of MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Topologically Incorrect Protein