CD180 and ADAMTS6

Data Source: HiPPIP (Novel)

		CD180	ADAMTS6
Name		CD180 molecule	ADAM metallopeptidase with thrombospondin type 1 motif 6
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Membrane Mitotic Spindle	Extracellular Region Extracellular Matrix
	Molecular Function	Lipopolysaccharide Immune Receptor Activity Protein Binding Signaling Receptor Activity	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	B Cell Proliferation Involved In Immune Response Immune System Process Inflammatory Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation Innate Immune Response Cellular Response To Lipopolysaccharide	Kidney Development Cardiac Septum Development Proteolysis Heart Development Extracellular Matrix Organization Aorta Development Coronary Vasculature Development
Pathways		Toll Like Receptor 4 (TLR4) Cascade	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
GWAS		Common carotid intima-media thickness in HIV infection ( 29206233 ) General cognitive ability ( 29844566 ) Gut microbiota (bacterial taxa) ( 27723756 )	A body shape index ( 34021172 ) Brain morphology (MOSTest) ( 32665545 ) Central corneal thickness ( 32528159 31798171 29760442 ) Corneal structure ( 23291589 ) Corpus callosum anterior volume ( 31530798 ) Cortical surface area (MOSTest) ( 32665545 ) Feeling tense ( 29500382 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Inguinal hernia ( 26686553 ) Intraocular pressure ( 29617998 29785010 30054594 ) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Non-response to bupropion and depression ( 27622933 ) Osteosarcoma ( 23727862 ) Schizophrenia ( 23212062 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		2 novel interactors: ADAMTS6 SELENOS	5 novel interactors: ARSB CD180 CDK7 ERCC8 PART1
Interacting Genes		1 interacting genes: LY86	1 interacting genes: SNTA1
Entrez ID		4064	11174
HPRD ID		03749	05421
Ensembl ID		ENSG00000134061	ENSG00000049192
Uniprot IDs		Q99467	Q5IR90 Q9UKP5
PDB IDs		3B2D	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER Overload Response Very-low-density Lipoprotein Particle Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of Glycogen Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Acute Inflammatory Response To Antigenic Stimulus Ubiquitin-specific Protease Binding Derlin-1 Retrotranslocation Complex Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Myeloid Cell Apoptotic Process Derlin-1-VIMP Complex Response To Redox State Regulation Of Lipopolysaccharide-mediated Signaling Pathway Aorta Development Coronary Vasculature Development Protein Exit From Endoplasmic Reticulum Regulation Of Myeloid Cell Apoptotic Process Antioxidant Activity Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipopolysaccharide-mediated Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Glycogen Metabolic Process Artery Development Cardiac Septum Development Cell Redox Homeostasis Regulation Of Acute Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Gluconeogenesis	Colon Epithelial Cell Migration RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Regulation Of Transcription-coupled Nucleotide-excision Repair N-acetylgalactosamine-4-sulfatase Activity Intestinal Epithelial Cell Migration