CD180 and LY86

Number of citations: 0 (PubMedID 9686597)
Data Source: HPRD (in vitro, in vivo)

		CD180	LY86
Name		CD180 molecule	lymphocyte antigen 86
Structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Membrane Mitotic Spindle	Extracellular Region
	Molecular Function	Lipopolysaccharide Immune Receptor Activity Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	B Cell Proliferation Involved In Immune Response Immune System Process Inflammatory Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation Innate Immune Response Cellular Response To Lipopolysaccharide	Immune System Process Inflammatory Response Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response
Pathways		Toll Like Receptor 4 (TLR4) Cascade	Toll Like Receptor 4 (TLR4) Cascade
GWAS		Common carotid intima-media thickness in HIV infection ( 29206233 ) General cognitive ability ( 29844566 ) Gut microbiota (bacterial taxa) ( 27723756 )	Chronic obstructive pulmonary disease ( 30804561 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Lung function (FEV1/FVC) ( 30804560 30175238 ) Major depressive disorder (broad) ( 20038947 ) Multiple sclerosis ( 31604244 ) Peak expiratory flow ( 30804560 ) Refractive error ( 32231278 ) Serum uric acid levels ( 30993211 ) Systolic blood pressure ( 31134134 ) Systolic blood pressure (education interaction) ( 31134134 ) Urate levels in overweight individuals ( 25811787 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534 ) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534 ) Waist-hip ratio ( 25673412 23966867 23563607 20935629 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )
Novel Interactors		2 novel interactors: ADAMTS6 SELENOS	1 novel interactors: STAT4
Interacting Genes		1 interacting genes: LY86	2 interacting genes: CD180 GEMIN4
Entrez ID		4064	9450
HPRD ID		03749	05578
Ensembl ID		ENSG00000134061	ENSG00000112799
Uniprot IDs		Q99467	O95711
PDB IDs		3B2D	3B2D
GO Terms Enriched among Interactors		Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER Overload Response Very-low-density Lipoprotein Particle Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of Glycogen Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Acute Inflammatory Response To Antigenic Stimulus Ubiquitin-specific Protease Binding Derlin-1 Retrotranslocation Complex Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of D-glucose Import Negative Regulation Of Myeloid Cell Apoptotic Process Derlin-1-VIMP Complex Response To Redox State Regulation Of Lipopolysaccharide-mediated Signaling Pathway Aorta Development Coronary Vasculature Development Protein Exit From Endoplasmic Reticulum Regulation Of Myeloid Cell Apoptotic Process Antioxidant Activity Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipopolysaccharide-mediated Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Glycogen Metabolic Process Artery Development Cardiac Septum Development Cell Redox Homeostasis Regulation Of Acute Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Gluconeogenesis	Leukocyte Activation Involved In Immune Response Lymphocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Immune Effector Process Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation Involved In Immune Response Lipopolysaccharide Immune Receptor Activity Lymphocyte Activation Nuclear Body Interleukin-12-mediated Signaling Pathway SMN Complex Gemini Of Cajal Bodies Leukocyte Activation T-helper 1 Cell Differentiation SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Response To Interleukin-6 Cell Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway B Cell Proliferation T Cell Differentiation Involved In Immune Response T-helper Cell Differentiation Ribonucleoprotein Complex Binding Spliceosomal SnRNP Assembly Nucleolus CD4-positive, Alpha-beta T Cell Differentiation