SELENOS and EIF2AK1

		SELENOS	EIF2AK1
Description		selenoprotein S	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis Intracellular Protein Transport ER Overload Response Response To Glucose Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress ERAD Pathway Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of D-glucose Import Negative Regulation Of Inflammatory Response Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Mitophagy Acute Inflammatory Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Phagocytosis Response To Stress Negative Regulation Of Cell Population Proliferation Negative Regulation Of Translation Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Hemoglobin Biosynthetic Process Establishment Of Localization In Cell Multicellular Organismal-level Iron Ion Homeostasis Protein Localization To Mitochondrion Integrated Stress Response Signaling HRI-mediated Signaling Positive Regulation Of Mitophagy Response To Iron Ion Starvation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Response of EIF2AK1 (HRI) to heme deficiency Cellular response to mitochondrial stress
Drugs			Fostamatinib
Diseases
GWAS			High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP	5 interacting genes: CDC37 EIF2S1 HSP90AA1 LCOR LIG4
Entrez ID		55829	27102
HPRD ID		12133	10684
Ensembl ID		ENSG00000131871	ENSG00000086232
Uniprot IDs		Q6GYA4 Q9BQE4	Q9BQI3
PDB IDs		2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Spliceosomal Complex Assembly Derlin-1 Retrotranslocation Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Protein-RNA Complex Assembly Retrograde Protein Transport, ER To Cytosol MHC Class I Protein Binding Ubiquitin-specific Protease Binding High-density Lipoprotein Particle Regulation Of MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Topologically Incorrect Protein	Ubiquitin-specific Protease Binding ER-nucleus Signaling Pathway Protein Folding Chaperone Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Response To Heat Translation Initiation Ternary Complex Cellular Response To Heat DNA Biosynthetic Process Unfolded Protein Binding CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Chromosome Organization UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Establishment Of Integrated Proviral Latency Establishment Of Viral Latency HSP90-CDC37 Chaperone Complex Derlin-1-VIMP Complex Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To Stress Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Response To Temperature Stimulus Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DN2 Thymocyte Differentiation Cellular Response To Radiation Cellular Response To Metal Ion Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Sperm Mitochondrial Sheath Protein Folding Regulation Of Defense Response Telomerase Holoenzyme Complex Assembly Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Cellular Response To Oxidative Stress HRI-mediated Signaling Response To Endoplasmic Reticulum Stress
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