LTB and LTA

Number of citations: 0 (PubMedID 7916655)
Data Source: HPRD (in vivo, in vitro)

		LTB	LTA
Name		lymphotoxin beta	lymphotoxin alpha
Structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Gene Expression Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development Lymph Node Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Immune Response Humoral Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Response To Nutrient Response To Xenobiotic Stimulus Signaling Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		None	Etanercept
GWAS		AIDS progression ( 19115949 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 21102463 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Neonatal lupus ( 20662065 ) Ulcerative colitis ( 28067908 )	A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 21102463 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Kawasaki disease ( 33106546 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Malaria ( 31844061 ) Monocyte count ( 32888494 ) Neonatal lupus ( 20662065 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Tumor necrosis factor levels ( 32805626 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 27863252 )
Interacting Genes		4 interacting genes: LTA LTBR TNFRSF1A TNFSF14	13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD
Entrez ID		4050	4049
HPRD ID		02987	01084
Ensembl ID		ENSG00000227507	ENSG00000226979
Uniprot IDs		Q06643 Q5STB2	P01374 Q5ST95 Q5STV3 Q6FG55
PDB IDs		4MXW	1TNR 4MXV 4MXW
GO Terms Enriched among Interactors		Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Inflammatory Response Regulation Of Signal Transduction Cytokine Activity Positive Regulation Of Chronic Inflammatory Response Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Immune Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Aortic Valve Development Semi-lunar Valve Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Developmental Process Defense Response To Bacterium Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Chronic Inflammatory Response Extracellular Space Tumor Necrosis Factor Receptor Activity Regulation Of Cell Differentiation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Response To Bacterium Signaling Receptor Binding Positive Regulation Of T Cell Chemotaxis	Tumor Necrosis Factor Receptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Aortic Valve Development Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Cytokine-mediated Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Programmed Cell Death Negative Regulation Of Muscle Hypertrophy Regulation Of Muscle System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Citric Acid Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Positive Regulation Of Deacetylase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Membrane Galectin Complex Ubiquitin Protein Ligase Binding Cellular Response To Mechanical Stimulus Regulation Of Extracellular Matrix Organization Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cardiac Muscle Hypertrophy Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Response To Unfolded Protein Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Juxtaglomerular Apparatus Development Defense Response To Gram-negative Bacterium