LTB

Name	lymphotoxin beta
Structure
Interactors	4 interactors: LTA LTBR TNFRSF1A TNFSF14
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Gene Expression Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development Lymph Node Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GWAS	AIDS progression ( 19115949 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 21102463 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Neonatal lupus ( 20662065 ) Ulcerative colitis ( 28067908 )
Entrez ID	4050
HPRD ID	02987
Ensembl ID	ENSG00000227507
Uniprot IDs	Q06643 Q5STB2
PDB IDs	4MXW
GO Terms Enriched among Interactors ?	Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Inflammatory Response Regulation Of Signal Transduction Cytokine Activity Positive Regulation Of Chronic Inflammatory Response Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Immune Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Aortic Valve Development Semi-lunar Valve Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Developmental Process Defense Response To Bacterium Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Chronic Inflammatory Response Extracellular Space Tumor Necrosis Factor Receptor Activity Regulation Of Cell Differentiation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Response To Bacterium Signaling Receptor Binding Positive Regulation Of T Cell Chemotaxis