LTB and LTBR

Number of citations of the paper that reports this interaction (PMID 7916655)
66

Data Source:
HPRD (in vitro)

		LTB	LTBR
Gene Name		lymphotoxin beta (TNF superfamily, member 3)	lymphotoxin beta receptor (TNFR superfamily, member 3)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Space Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Skin Development Positive Regulation Of Interleukin-12 Biosynthetic Process Lymph Node Development	Apoptotic Process Signal Transduction Viral Process Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		4 interactors: LTA LTBR TNFRSF1A TNFSF14	13 interactors: BIRC2 DIABLO HES1 LTA LTB TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Entrez ID		4050	4055
HPRD ID		02987	02988
Ensembl ID		ENSG00000227507	ENSG00000111321
Uniprot IDs		Q06643 Q5STB2	P36941
PDB IDs			1RF3
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To Mechanical Stimulus Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of Cell Death Response To External Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response To Bacterium Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Inflammatory Response Response To Hypoxia Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Response To Bacterium Signal Transduction Leukocyte Activation Positive Regulation Of Glial Cell Proliferation	Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling Cell Communication Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Binding Lymph Node Development Regulation Of Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Homodimerization Activity Regulation Of Peptidase Activity Immune System Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Signaling Activation Of Innate Immune Response Regulation Of JNK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour	affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded
Tagcloud (Difference) ?		31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour	affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded
Tagcloud (Intersection) ?