LTB and TNFSF14

Number of citations: 0 (PubMedID 10318773)
Data Source: HPRD (in vitro)

		LTB	TNFSF14
Name		lymphotoxin beta	TNF superfamily member 14
Structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Gene Expression Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development Lymph Node Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Chemotaxis Positive Regulation Of T Cell Chemotaxis Signaling T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Fusion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GWAS		AIDS progression ( 19115949 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 21102463 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Neonatal lupus ( 20662065 ) Ulcerative colitis ( 28067908 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 27863252 ) Multiple sclerosis ( 21833088 24076602 31604244 )
Novel Interactors		None recorded	3 novel interactors: S1PR4 SLC38A3 TCF3
Interacting Genes		4 interacting genes: LTA LTBR TNFRSF1A TNFSF14	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		4050	8740
HPRD ID		02987	05157
Ensembl ID		ENSG00000227507	ENSG00000125735
Uniprot IDs		Q06643 Q5STB2	O43557
PDB IDs		4MXW	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU 7MSG
GO Terms Enriched among Interactors		Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Inflammatory Response Regulation Of Signal Transduction Cytokine Activity Positive Regulation Of Chronic Inflammatory Response Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Immune Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Aortic Valve Development Semi-lunar Valve Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Developmental Process Defense Response To Bacterium Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Chronic Inflammatory Response Extracellular Space Tumor Necrosis Factor Receptor Activity Regulation Of Cell Differentiation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Response To Bacterium Signaling Receptor Binding Positive Regulation Of T Cell Chemotaxis	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Membrane Regulation Of Apoptotic Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Cytokine Activity Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules