LTB and TNFSF14

Number of citations of the paper that reports this interaction (PMID 10318773)
55

Data Source:
HPRD (in vitro)

		LTB	TNFSF14
Gene Name		lymphotoxin beta (TNF superfamily, member 3)	tumor necrosis factor (ligand) superfamily, member 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Space Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Skin Development Positive Regulation Of Interleukin-12 Biosynthetic Process Lymph Node Development	Apoptotic Process Immune Response Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Chemotaxis T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		4 interactors: LTA LTBR TNFRSF1A TNFSF14	5 interactors: APP LTB LTBR TNFRSF14 TNFRSF6B
Entrez ID		4050	8740
HPRD ID		02987	05157
Ensembl ID		ENSG00000227507	ENSG00000125735
Uniprot IDs		Q06643 Q5STB2	O43557
PDB IDs			4EN0 4J6G 4KG8 4KGG 4KGQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To Mechanical Stimulus Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of Cell Death Response To External Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response To Bacterium Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Inflammatory Response Response To Hypoxia Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Response To Bacterium Signal Transduction Leukocyte Activation Positive Regulation Of Glial Cell Proliferation	Programmed Cell Death Cell Death Death Immune System Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of Phosphorylation Neuron Remodeling Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of T Cell Migration Lymph Node Development Cellular Copper Ion Homeostasis Response To External Stimulus Regulation Of T Cell Migration Regulation Of Cellular Ketone Metabolic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Lymphocyte Migration Regulation Of Protein Metabolic Process Mating Behavior Defense Response To Gram-negative Bacterium Endoplasmic Reticulum Calcium Ion Homeostasis Tumor Necrosis Factor-mediated Signaling Pathway Cell Activation
Tagcloud ?		31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1
Tagcloud (Difference) ?		31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1
Tagcloud (Intersection) ?