NPAS4 and ARNTL

Number of citations of the paper that reports this interaction (PMID 14701734)
30

Data Source:
HPRD (two hybrid)

		NPAS4	ARNTL
Gene Name		neuronal PAS domain protein 4	aryl hydrocarbon receptor nuclear translocator-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Transcription Factor Complex PML Body Chromatoid Body
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Signal Transducer Activity Protein Heterodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter	Protein Import Into Nucleus, Translocation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Menarche (age at onset) ( 21102462) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Schizophrenia ( 23358160)
Protein-Protein Interactions		3 interactors: ARNT ARNT2 ARNTL	20 interactors: AHR BHLHE40 CLOCK CRY1 CSNK1E EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RXRA SIRT1 SUMO2 SUMO3 UBE2I
Entrez ID		266743	406
HPRD ID		12260	03973
Ensembl ID		ENSG00000174576	ENSG00000133794
Uniprot IDs		Q8IUM7	O00327
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Hypoxia Oxidative Stress-induced Premature Senescence Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Skeletal Muscle Cell Differentiation Stress-induced Premature Senescence Response To Oxidative Stress Transcription, DNA-templated Negative Regulation Of Glucocorticoid Receptor Signaling Pathway RNA Biosynthetic Process Response To Redox State Positive Regulation Of Cellular Metabolic Process Regulation Of Type B Pancreatic Cell Development In Utero Embryonic Development Positive Regulation Of Hormone Biosynthetic Process MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Positive Regulation Of Protein Sumoylation Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm MRNA Transcription Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Protein Sumoylation RNA Metabolic Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Cellular Senescence Regulation Of Hair Cycle Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Gene Expression Cellular Senescence Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Protein Import Into Nucleus, Translocation Regulation Of Glycolytic Process Regulation Of Hormone Biosynthetic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Negative Regulation Of TOR Signaling Positive Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Rhythmic Process Circadian Regulation Of Gene Expression Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Peptidyl-lysine Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Peptidyl-amino Acid Modification Signal Transduction Protein Sumoylation Regulation Of Cellular Process Regulation Of Circadian Rhythm Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Cellular Response To Hypoxia Response To Abiotic Stimulus
Tagcloud ?		accumbens acetylated acetyltransferase addiction atf2 causal cck cholecystokinin corticotropin crf deacetylases fosb h3k18ac h3k9ac h4k5 h4k8 hat hats hdac1 hdac2 hdacs injection longterm meth methamphetamine nac neuropsychiatric psychostimulants releasing	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Difference) ?		accumbens acetylated acetyltransferase addiction atf2 causal cck cholecystokinin corticotropin crf deacetylases fosb h3k18ac h3k9ac h4k5 h4k8 hat hats hdac1 hdac2 hdacs injection longterm meth methamphetamine nac neuropsychiatric psychostimulants releasing	244k agilent bisulfite chemosensitivity chip circadian clock cobra cp70 cpg deadly epigenetically fifth gsk126 gynecological h3k27me3 hallmark hypermethylation island mark mcp2 medip methylated microarray ovarian repressive restored rhythmic silenced
Tagcloud (Intersection) ?