NPAS4 and BMAL1

Number of citations of the paper that reports this interaction (PubMedID 14701734)
32

Data Source:
HPRD (two hybrid)

		NPAS4	BMAL1
Description		neuronal PAS domain protein 4	basic helix-loop-helix ARNT like 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Postsynapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Chromatoid Body Aryl Hydrocarbon Receptor Complex CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Aryl Hydrocarbon Receptor Binding Sequence-specific DNA Binding Protein Dimerization Activity Hsp90 Protein Binding E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Learning Short-term Memory Long-term Memory Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Cellular Response To Stress Social Behavior Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Cellular Response To Corticosterone Stimulus Inhibitory Synapse Assembly	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Regulation of NPAS4 mRNA translation NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes	BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) General risk tolerance (MTAG) ( 30643258) Left-handedness ( 32989287) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: ARNT ARNT2 BMAL1 MAGED1	25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12
Entrez ID		266743	406
HPRD ID		12260	03973
Ensembl ID		ENSG00000174576	ENSG00000133794
Uniprot IDs		Q8IUM7	A0A140VKD3 A0A669KBF4 B2RCL8 O00327
PDB IDs			4H10 8RW6 8RW8
Enriched GO Terms of Interacting Partners?		Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Protein Dimerization Activity Transcription Regulator Complex Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Oxidative Stress-induced Premature Senescence DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CLOCK-BMAL Transcription Complex Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Acetylation Stress-induced Premature Senescence Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Hypoxia Positive Regulation Of Developmental Process Response To Decreased Oxygen Levels Intestinal Epithelial Structure Maintenance Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Response To Oxygen Levels Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Sumoylation Chromatoid Body Regulation Of Cell Population Proliferation Response To Redox State Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Transcription Regulator Complex Chromatin Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Transcription Coactivator Binding E-box Binding Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Photoperiodism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Protein Acetylation Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Response To Light Stimulus Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Circadian Rhythm Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hexose Biosynthetic Process Regulation Of Multicellular Organismal Process Nucleus Positive Regulation Of Metabolic Process Response To Radiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod
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