SIGLEC12 and DNAJC30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIGLEC12	DNAJC30
Description		sialic acid binding Ig like lectin 12	DnaJ heat shock protein family (Hsp40) member C30
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding	Protein Binding
	Biological Process	Cell Adhesion	ATP Biosynthetic Process Brain Development Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		17 interacting genes: ACSF2 ADIPOQ ATP5PF CDIPT CLEC4G CMAS CTSA DNAJC30 IL1RL1 MGST1 PLPP6 PLPPR2 PTCH1 PTPN11 PTPN6 TMPRSS4 YIPF1	30 interacting genes: AQP6 BEST2 CALN1 CREB3 EBP EXOSC6 FAM209A FATE1 FBXO7 GPX8 JAGN1 KASH5 LMNA LRRC25 MGST2 MRM1 MSMO1 OPRL1 PEX12 REEP4 RNF170 S100B SIGLEC12 SLC10A4 SLC35H1 SLC51A SLC71A2 TMEM31 TMEM52B TMEM86B
Entrez ID		89858	84277
HPRD ID		16195	10303
Ensembl ID		ENSG00000254521	ENSG00000176410
Uniprot IDs		Q96PQ1	B3KSU4 Q96LL9
PDB IDs			2YUA
Enriched GO Terms of Interacting Partners?		Regulation Of Neutrophil Activation Phosphate-containing Compound Metabolic Process Dephosphorylation Organophosphate Metabolic Process Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Adaptive Immune Response Negative Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Proliferation Neutrophil Activation Involved In Immune Response Brain Development Phosphatidate Phosphatase Activity Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Immune System Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Viral Life Cycle Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Transport Negative Regulation Of T Cell Activation Negative Regulation Of Cytokine Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Lipid Modification Cellular Response To Lipid Hydroperoxide Negative Regulation Of Cell Population Proliferation Neural Plate Axis Specification Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cholesterol Transport Reproductive Structure Development Cytokine-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production T Cell Costimulation Regulation Of Cytokine-mediated Signaling Pathway Epididymis Development Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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