CLN5 and GPR152

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLN5	GPR152
Description		CLN5 lysosomal BMP synthase	G protein-coupled receptor 152
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Lumen Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding D-mannose Binding Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Long-chain Fatty Acyl-CoA Hydrolase Activity Bis(monoacylglycero)phosphate Synthase Activity	G Protein-coupled Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Peptide Processing Lysosome Organization Lysosomal Lumen Acidification Brain Development Visual Perception Neurogenesis Protein Catabolic Process Retrograde Transport, Endosome To Golgi Neuron Maturation Glycosylation Positive Regulation Of GTP Binding	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 34099189) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: FDFT1 GPR152 IGF2 INS-IGF2 OGT PLPP6 SLC41A1 SLC41A2 TMEM31	197 interacting genes: ABCG4 ABHD16A ACSF2 ADIPOQ AGTRAP AIG1 ANKRD46 APOL3 AQP10 AQP3 AQP6 ARL6IP1 ARV1 ATP6V0C B3GNT7 BDNF BET1 BMP10 BNIP2 BNIP3 C14orf180 C1QL4 C8A CCDC167 CCL4 CCL4L2 CD53 CD72 CD81 CDIPT CDS2 CGRRF1 CLDND2 CLEC17A CLEC1A CLN5 CNIH1 COL8A2 COMT CRISP3 CSGALNACT2 CTXN3 CYB561 CYB561A3 CYB5B CYB5R3 CYBC1 DEFB108B DGAT2L6 EBP EDDM3B EFNA5 EMD ERG28 ERGIC3 FA2H FAM209A FAM20B FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6-FXYD2 GAST GJB2 GOLT1A GOLT1B GOSR2 GPR151 GPR37L1 HHATL HMOX1 HMOX2 IFNA8 IGF2 IGFBP5 IL1RL1 INS-IGF2 INSIG2 JAGN1 KCNA1 KCNN4 LAMB1 LAT LEPROTL1 LHFPL2 LHFPL5 LTC4S MAL MAL2 MFF MFSD6 MGLL MGST3 MMD MOSPD3 MS4A13 MYADML2 NAT8 NDUFB11 NEU1 NINJ2 NIPAL4 ORMDL1 ORMDL3 PEDS1-UBE2V1 PEX16 PGAP2 PIGF PIN1 PLN PNLIPRP1 PRAF2 PROM2 PTPRN RABAC1 RBFA REEP6 ROBO2 RTN3 RTP2 SACM1L SCAMP4 SCD SEC22B SERF1A SERF1B SERP2 SFT2D2 SFTPC SLC10A1 SLC13A4 SLC29A2 SLC30A3 SLC35A4 SLC35B1 SLC35B4 SLC35F6 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SMCO4 STATH STX1B STX3 STX4 STX5 STX8 SYT15 SYT15B TAP1 TEX264 TFRC THBD THSD7B TIMMDC1 TM4SF19 TMEM100 TMEM120B TMEM128 TMEM140 TMEM14B TMEM14C TMEM201 TMEM208 TMEM218 TMEM236 TMEM237 TMEM243 TMEM254 TMEM42 TMEM50B TMEM54 TMEM60 TMEM97 TMPPE TNFRSF10C TSNARE1 TSPAN33 TSPAN7 TSPO2 UBIAD1 UNC50 VAMP1 VAMP4 VAMP5 VKORC1 YIPF1 YIPF4 YIPF6 ZDHHC15
Entrez ID		1203	390212
HPRD ID		07619	13599
Ensembl ID		ENSG00000102805	ENSG00000175514
Uniprot IDs		A0A1B0GTR6 O75503	A0A0I9RJ67 Q8TDT2
PDB IDs		6R99
Enriched GO Terms of Interacting Partners?		Farnesyl Diphosphate Metabolic Process Inorganic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Insulin Receptor Binding Cholesterol Biosynthetic Process Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Terpenoid Metabolic Process Steroid Biosynthetic Process Nickel Cation Transport Magnesium:sodium Antiporter Activity Regulation Of Glucose Metabolic Process Isoprenoid Metabolic Process Cholesterol Metabolic Process Hormone Activity Protein O-acetylglucosaminyltransferase Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Sterol Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Embryonic Placenta Morphogenesis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Intracellular Magnesium Ion Homeostasis Cellular Response To Magnesium Ion Lipid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Regulation Of Skeletal Muscle Tissue Growth Carbon Catabolite Regulation Of Transcription Lysophosphatidic Acid Phosphatase Activity Cobalt Ion Transport Regulation Of Transcription By Glucose Protein Prenylation Exocrine Pancreas Development NSL Complex Regulation Of Neutrophil Activation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Golgi Membrane Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sterol Biosynthetic Process SNARE Binding Vesicle-mediated Transport Membrane Organization Membrane Fusion Lipid Biosynthetic Process Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Cellular Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Organization Golgi Apparatus Cholesterol Biosynthetic Process Steroid Biosynthetic Process Membrane Docking Vesicle Docking Cortical Endoplasmic Reticulum Basolateral Plasma Membrane Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Lysine Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Organelle Membrane Cholesterol Binding Nuclear Inner Membrane Organelle Localization By Membrane Tethering SNARE Complex Assembly Trans-Golgi Network Amyloid Fibril Formation Establishment Of Localization In Cell Establishment Of Protein Localization Nitric-oxide Synthase Complex UDP-glucose Transmembrane Transport Golgi Vesicle Transport Amino Acid Transmembrane Transport Water Channel Activity
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