VLDLR and CD36

Number of citations of the paper that reports this interaction (PMID 9555943)
43

Data Source:
BioGRID (pull down)

		VLDLR	CD36
Gene Name		very low density lipoprotein receptor	CD36 molecule (thrombospondin receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Membrane Raft Phagocytic Vesicle
	Molecular Function	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Glycoprotein Transporter Activity Reelin Receptor Activity Calcium-dependent Protein Binding	Low-density Lipoprotein Receptor Activity High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Dendrite Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Cell Adhesion Cell Surface Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Plasma Membrane Long-chain Fatty Acid Transport Lipid Storage CGMP-mediated Signaling Platelet Activation Positive Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Lipoprotein Transport Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Negative Regulation Of Growth Of Symbiont In Host Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Hydroperoxide Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			PPARA activates gene expression Metabolism of lipids and lipoproteins Platelet degranulation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Gambling ( 22780124) Vascular endothelial growth factor levels ( 21757650)	HDL cholesterol ( 23726366) Left ventricular mass ( 19454037) Mean platelet volume ( 22423221) Response to fenofibrate ( 22890011)
Protein-Protein Interactions		9 interactors: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17	18 interactors: APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1
Entrez ID		7436	948
HPRD ID		01895	01430
Ensembl ID		ENSG00000147852	ENSG00000135218
Uniprot IDs		P98155 Q5VVF5	A4D1B1 P16671
PDB IDs		1V9U 3DPR
Enriched GO Terms of Interacting Partners?		Regulation Of Beta-amyloid Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Lateral Motor Column Neuron Migration Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Cholesterol Transport Sterol Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Beta-amyloid Formation Triglyceride-rich Lipoprotein Particle Remodeling Receptor-mediated Endocytosis CGMP-mediated Signaling Cholesterol Catabolic Process Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Cell Differentiation Lipid Homeostasis Positive Regulation Of Cholesterol Storage Negative Regulation Of Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Regulation Of Beta-amyloid Formation Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Triglyceride Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Steroid Catabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Acylglycerol Catabolic Process Glial Cell Differentiation Plasma Lipoprotein Particle Remodeling Regulation Of Protein Metabolic Process Positive Regulation Of Dendritic Spine Development Lipid Metabolic Process Positive Regulation Of Lipid Storage Postsynaptic Membrane Organization Regulation Of Phosphorylation Plasma Lipoprotein Particle Clearance Cyclic-nucleotide-mediated Signaling Positive Regulation Of Protein Catabolic Process Endocytosis Cellular Localization Gliogenesis	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Leukocyte Migration Movement Of Cell Or Subcellular Component Locomotion Cell Activation Anatomical Structure Morphogenesis Vesicle-mediated Transport Cell Migration Cell Motility Endocytosis Platelet Degranulation Anatomical Structure Development Peptidyl-tyrosine Autophosphorylation System Development Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cell Adhesion Developmental Process Response To External Stimulus Multicellular Organismal Development Axonogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Differentiation Positive Regulation Of Cellular Component Movement Response To Stress Immune System Process Axon Development Positive Regulation Of Locomotion Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Regulation Of Cell Motility Neuron Projection Morphogenesis Organ Development Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Abiotic Stimulus Cell Projection Organization
Tagcloud ?		1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Difference) ?		1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Intersection) ?