VLDLR and ZSCAN12

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VLDLR	ZSCAN12
Name		very low density lipoprotein receptor	zinc finger and SCAN domain containing 12
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Very-low-density Lipoprotein Particle Receptor Complex Synapse Glutamatergic Synapse	Nucleus
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Steroid Metabolic Process Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Dendrite Morphogenesis Regulation Of Synapse Assembly Positive Regulation Of Dendrite Development	Regulation Of Transcription By RNA Polymerase II
Pathways		Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance	None
Drugs		Lauric acid	None
GWAS		Alzheimer's disease (age of onset) ( 22005931 ) Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Cytokine levels ( 31679650 ) Cytokine network levels (multivariate analysis) ( 31679650 ) Gambling ( 22780124 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) LDL cholesterol ( 30275531 24097068 ) LDL cholesterol levels ( 28334899 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 32888494 ) Systolic blood pressure ( 26969751 ) Total cholesterol levels ( 30275531 ) Vascular endothelial growth factor levels ( 21757650 31217265 27989323 26910538 ) White blood cell count ( 32888494 ) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621 )	Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 33909500 ) Fish- and plant-related diet ( 32066663 ) Lung cancer ( 28604730 ) Refractive error ( 32231278 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Sleep duration (short sleep) ( 30846698 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Squamous cell lung carcinoma ( 28604730 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		1 novel interactors: CD274	None recorded
Interacting Genes		12 interacting genes: APOE CD36 CLU DAB1 DYRK1A ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12	26 interacting genes: BICD2 CENPH CEP70 FAM161A KRTAP10-1 KRTAP10-8 LMNA MID2 MTUS2 PGBD1 RACK1 SCAND1 SRPK2 SSX2IP TFIP11 VCX VLDLR VPS26A ZKSCAN7 ZNF24 ZNF397 ZNF446 ZNF473 ZNF496 ZSCAN21 ZSCAN32
Entrez ID		7436	9753
HPRD ID		01895	15767
Ensembl ID		ENSG00000147852	ENSG00000158691
Uniprot IDs		A0A7P0T897 A0A7P0T8N9 A0A7P0T9P7 P98155 Q5VVF5	A0A804HJ42 O43309
PDB IDs		1V9U 3DPR 6BYV 8IHP 8UA4 8UA8 8UFB 8UFC 8X0K 8X0L 8X0M 8XI4 8XI5 8YS2 8YS4 8YVZ 8YW0 8YW1 8YW2	Not available
GO Terms Enriched among Interactors		Very-low-density Lipoprotein Particle Receptor Binding Low-density Lipoprotein Particle Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Particle Binding Receptor Ligand Activity Regulation Of Endocytosis Regulation Of Inclusion Body Assembly Amyloid-beta Binding Regulation Of Amyloid-beta Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Cellular Component Organization Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Vesicle-mediated Transport Lateral Motor Column Neuron Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Dendritic Spine Development Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Very-low-density Lipoprotein Particle Clearance Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Regulation Of Dendritic Spine Development Receptor-mediated Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Protein Import Positive Regulation Of Cholesterol Storage Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Regulation Of Nitric Oxide Metabolic Process Ventral Spinal Cord Development Cholesterol Transport Nitric Oxide-cGMP-mediated Signaling Triglyceride-rich Lipoprotein Particle Remodeling Sterol Transport Regulation Of Amide Metabolic Process Reelin-mediated Signaling Pathway Neurotransmitter-gated Ion Channel Clustering Cholesterol Homeostasis Chylomicron	None