LOX and ELN

Number of citations of the paper that reports this interaction (PMID 6912069)
5

Data Source:
HPRD (in vivo)

		LOX	ELN
Gene Name		lysyl oxidase	elastin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Extracellular Space Nucleus	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Blood Vessel Development Cellular Protein Modification Process Extracellular Matrix Organization Collagen Fibril Organization Lung Development Wound Healing Response To Drug Elastic Fiber Assembly Response To Steroid Hormone Oxidation-reduction Process	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Collagen formation Crosslinking of collagen fibrils Elastic fibre formation Assembly of collagen fibrils and other multimeric structures	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs			Rofecoxib
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		7 interactors: DHDDS DPT ELN HIST1H1A HIST1H1B HIST1H2BJ HIST2H2BE	21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1
Entrez ID		4015	2006
HPRD ID		01087	00556
Ensembl ID		ENSG00000113083	ENSG00000049540
Uniprot IDs		B7ZAJ4 D0PNI2 P28300	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging DNA Conformation Change Innate Immune Response In Mucosa Cellular Macromolecular Complex Assembly Antibacterial Humoral Response Chromatin Organization Antimicrobial Humoral Response Mucosal Immune Response Cellular Component Assembly Chromosome Organization Protein Complex Assembly Defense Response To Gram-positive Bacterium Organelle Organization Defense Response To Bacterium Dolichyl Diphosphate Biosynthetic Process Establishment Of Protein Localization To Chromatin Humoral Immune Response Protein Localization To Chromatin Positive Regulation Of Histone H3-K9 Methylation Stress Fiber Assembly Extracellular Matrix Organization Extracellular Structure Organization Response To Bacterium Protein Localization To Chromosome Positive Regulation Of Histone Methylation	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?