LMX1B and NPHS2

Number of citations of the paper that reports this interaction (PubMedID 24854274)
48

Data Source:
BioGRID (pull down)

		LMX1B	NPHS2
Description		LIM homeobox transcription factor 1 beta	NPHS2 stomatin family member, podocin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Protein-containing Complex Slit Diaphragm Membrane Raft Extracellular Exosome Cell Periphery
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Pattern Formation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Dopaminergic Neuron Differentiation	Glomerular Filtration Gene Expression Actin Cytoskeleton Organization Renal System Development Metanephric Podocyte Development
Pathways			Nephrin family interactions
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Body mass index ( 28892062 20935630 28552196 26961502 25673413) Body size at age 10 ( 32376654) Breast cancer ( 31757997 29059683) C-reactive protein levels ( 31622379) Calcium levels ( 29403010) Childhood body mass index ( 33045005 26604143) Chin dimples ( 27182965) Eyebrow thickness ( 26926045) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673 29449654) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594 29785010 29617998 31959993) Medication use (antiglaucoma preparations and miotics) ( 31015401) Mental health related quality of life ( 33578652) Monobrow ( 27182965) Multiple system atrophy ( 27629089) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Social communication problems ( 24564958) Trunk fat mass ( 28552196)
Interacting Genes		7 interacting genes: APP CFTR CREB5 HOXA1 LDB1 NPHS2 TCF3	7 interacting genes: CD2AP FOXC1 FOXC2 KIRREL1 KIRREL3 LMX1B NPHS1
Entrez ID		4010	7827
HPRD ID		03986	05303
Ensembl ID		ENSG00000136944	ENSG00000116218
Uniprot IDs		B7ZLH2 O60663 Q6ISE0	Q9NP85
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding System Development Visual Behavior Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Semicircular Canal Formation Chromatin Renal System Development Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Abducens Nerve Formation Optokinetic Behavior Vitamin D Response Element Binding RNA Polymerase II Transcription Regulator Complex Metanephric Podocyte Development Recycling Endosome Response To Purine-containing Compound Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Involved In Outflow Tract Morphogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Cell-cell Junction Apoptotic Process Involved In Heart Morphogenesis Glomerular Epithelium Development Paraxial Mesoderm Formation Renal Protein Absorption Slit Diaphragm Cell Adhesion Molecule Binding Lymph Vessel Development Endothelium Development Podocyte Differentiation Cell Junction Organization Cell-cell Adhesion Kidney Development Embryonic Heart Tube Development Apoptotic Process Involved In Morphogenesis Cell-cell Junction Organization Myosin Binding Neural Crest Cell Development Cardiac Muscle Cell Proliferation Cell Differentiation Involved In Kidney Development Apoptotic Process Involved In Development Stem Cell Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Development Extracellular Matrix Organization Tissue Development Extracellular Structure Organization Ureteric Bud Development Dendritic Shaft Blood Vessel Remodeling Regionalization Renal Absorption Cellular Developmental Process Muscle Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Somitogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Actin Filament Polymerization Segmentation Cell Adhesion Cell Development Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Regulation Of Actin Cytoskeleton Organization
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