LMX1B and TCF3

Number of citations of the paper that reports this interaction (PMID 9199284)
16

Data Source:
HPRD (in vitro)

		LMX1B	TCF3
Gene Name		LIM homeobox transcription factor 1, beta	transcription factor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	In Utero Embryonic Development Neuron Migration Trabecular Meshwork Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cell Proliferation Dorsal/ventral Pattern Formation Cerebellum Morphogenesis Central Nervous System Neuron Development Neuron Differentiation Collagen Fibril Organization Midbrain Development Limb Morphogenesis Organ Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Dopaminergic Neuron Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Response To Drug Muscle Cell Differentiation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Peyer's Patch Development Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Body mass index ( 20935630)
Protein-Protein Interactions		4 interactors: APP LDB1 SSBP3 TCF3	62 interactors: AEBP1 ASCL3 BHLHA15 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DAXX ELK3 EP300 FERD3L HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MAX MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NHLH1 PDX1 PRKACA PSMD4 PSMD9 RALGAPA1 RPL37 RUFY1 RUNX1T1 SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1 VDR
Entrez ID		4010	6929
HPRD ID		03986	00918
Ensembl ID		ENSG00000136944	ENSG00000071564
Uniprot IDs		B7ZLH2 O60663 Q6ISE0	P15923 Q2TB39
PDB IDs			1HLH 2YPA 2YPB 3U5V
Enriched GO Terms of Interacting Partners?		Brain Development Head Development Central Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Histone Acetylation Axis Specification Internal Peptidyl-lysine Acetylation Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Histone H3-K4 Acetylation Midbrain-hindbrain Boundary Initiation Prechordal Plate Formation Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein Acetylation Stem Cell Maintenance Organ Development Positive Regulation Of Hemoglobin Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Anterior Head Development RNA Metabolic Process Embryo Development Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Collateral Sprouting In Absence Of Injury Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Mitotic Cell Cycle Phase Transition Skin Development Regulation Of Cell Cycle Phase Transition Neural Plate Anterior/posterior Regionalization Stem Cell Development Peptidyl-lysine Modification Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Hemoglobin Biosynthetic Process Wnt Signaling Pathway	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organ Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Anatomical Structure Development Multicellular Organismal Development Developmental Process Embryo Development Tissue Development Organ Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Embryonic Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Embryonic Organ Development
Tagcloud ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm en1 eventually fgfs limb limbs malformation manners modules organized p63 quantity shh sterile wnt7a zpa	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Difference) ?		aer alternatives assure axes brief brought clues complements congenital correct deciphering deformity digit ectoderm en1 eventually fgfs limb limbs malformation manners modules organized p63 quantity shh sterile wnt7a zpa	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Intersection) ?