LMX1B

Name	LIM homeobox transcription factor 1 beta
Structure	No pdb structure
Interactors	7 interactors: APP CFTR CREB5 HOXA1 LDB1 NPHS2 TCF3
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Pattern Formation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Dopaminergic Neuron Differentiation
Diseases	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body fat mass ( 28552196 ) Body mass index ( 28892062 20935630 28552196 26961502 25673413 ) Body size at age 10 ( 32376654 ) Breast cancer ( 31757997 29059683 ) C-reactive protein levels ( 31622379 ) Calcium levels ( 29403010 ) Childhood body mass index ( 33045005 26604143 ) Chin dimples ( 27182965 ) Eyebrow thickness ( 26926045 ) Glaucoma ( 31959993 30054594 ) Glaucoma (high intraocular pressure) ( 33627673 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 29891935 33627673 29449654 ) Heel bone mineral density ( 30598549 ) Intraocular pressure ( 30054594 29785010 29617998 31959993 ) Medication use (antiglaucoma preparations and miotics) ( 31015401 ) Mental health related quality of life ( 33578652 ) Monobrow ( 27182965 ) Multiple system atrophy ( 27629089 ) Open-angle glaucoma and optic cup area ( 29449654 ) Osteoarthritis (hip) ( 30374069 ) Social communication problems ( 24564958 ) Trunk fat mass ( 28552196 )
Entrez ID	4010
HPRD ID	03986
Ensembl ID	ENSG00000136944
Uniprot IDs	B7ZLH2 O60663 Q6ISE0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein-containing Complex Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding System Development Visual Behavior Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Semicircular Canal Formation Chromatin Renal System Development Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Abducens Nerve Formation Optokinetic Behavior Vitamin D Response Element Binding RNA Polymerase II Transcription Regulator Complex Metanephric Podocyte Development Recycling Endosome Response To Purine-containing Compound Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway