LLGL1 and USP11

Number of citations of the paper that reports this interaction (PubMedID 26919101)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LLGL1	USP11
Description		LLGL scribble cell polarity complex component 1	ubiquitin specific peptidase 11
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Cytoplasm Endosome Golgi Apparatus Cytoskeleton Plasma Membrane Adherens Junction Membrane Axon Cortical Actin Cytoskeleton Early Endosome Membrane Trans-Golgi Network Membrane Cell Projection	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Myosin II Binding	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Regulation Of Notch Signaling Pathway Cortical Actin Cytoskeleton Organization Regulation Of Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Spindle Orientation Protein-containing Complex Assembly	Proteolysis Protein Deubiquitination
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) LDL cholesterol ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: ACD AGTR1 CACNA1A CD46 STX4 UBC USP11	26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC
Entrez ID		3996	8237
HPRD ID		02982	02081
Ensembl ID		ENSG00000131899	ENSG00000102226
Uniprot IDs		Q15334	G5E9A6
PDB IDs		8R3Y
Enriched GO Terms of Interacting Partners?			Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound
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