LLGL1 and CD46

Number of citations of the paper that reports this interaction (PubMedID 11714708)
0

Data Source:
HPRD (in vitro, two hybrid)

		LLGL1	CD46
Description		LLGL scribble cell polarity complex component 1	CD46 molecule
Image
GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Cytoplasm Endosome Golgi Apparatus Cytoskeleton Plasma Membrane Adherens Junction Membrane Axon Cortical Actin Cytoskeleton Early Endosome Membrane Trans-Golgi Network Membrane Cell Projection	Inner Acrosomal Membrane Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	GTPase Activator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Myosin II Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Regulation Of Notch Signaling Pathway Cortical Actin Cytoskeleton Organization Regulation Of Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Spindle Orientation Protein-containing Complex Assembly	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production
Pathways			Regulation of Complement cascade
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) LDL cholesterol ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Keratoconus ( 33649486) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656 25056061) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ACD AGTR1 CACNA1A CD46 STX4 UBC USP11	14 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN POU4F2 SRC TSPAN4 VTI1B YES1
Entrez ID		3996	4179
HPRD ID		02982	00406
Ensembl ID		ENSG00000131899	ENSG00000117335
Uniprot IDs		Q15334	A0A8Q3WLA6 P15529
PDB IDs		8R3Y	1CKL 2O39 3INB 3L89 3O8E 5FO8 8QK3
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cellular Component Organization Regulation Of Transport Leukocyte Migration Regulation Of D-glucose Transmembrane Transport Protein Kinase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Negative Regulation Of Neuron Differentiation Focal Adhesion Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Cell Projection Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Regulation Of Endocytosis Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Anoikis Integrin Binding Perinuclear Region Of Cytoplasm Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Binding Establishment Or Maintenance Of Cell Polarity Cellular Response To Fluid Shear Stress Antigen Binding Plasma Membrane Fc-gamma Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Cellular Response To Peptide Hormone Stimulus Vesicle Cell Projection Positive Regulation Of Protein Localization Regulation Of Cellular Component Organization Developmental Maturation Positive Regulation Of Transport C5L2 Anaphylatoxin Chemotactic Receptor Binding Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Developmental Process P2Y1 Nucleotide Receptor Binding Adherens Junction
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