LLGL1 and CD46

Number of citations of the paper that reports this interaction (PMID 11714708)
11

Data Source:
HPRD (in vitro, two hybrid)

		LLGL1	CD46
Gene Name		lethal giant larvae homolog 1 (Drosophila)	CD46 molecule, complement regulatory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Cytoplasm Cytoskeleton Axon Cortical Actin Cytoskeleton Early Endosome Membrane Trans-Golgi Network Membrane Myelin Sheath Abaxonal Region	Inner Acrosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding	Complement Binding Endopeptidase Activity Enzyme Inhibitor Activity Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Protein Complex Assembly Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Cortical Actin Cytoskeleton Organization Positive Regulation Of Rab GTPase Activity Maintenance Of Apical/basal Cell Polarity	Adaptive Immune Response T Cell Mediated Immunity Proteolysis Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Negative Regulation Of Catalytic Activity Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production
Pathways			Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Heart rate ( 23583979) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: ACD CACNA1A CD46 STX4	8 interactors: C3 DLG4 ITGB1 LLGL1 MSN SRC TSPAN4 YES1
Entrez ID		3996	4179
HPRD ID		02982	00406
Ensembl ID		ENSG00000131899	ENSG00000117335
Uniprot IDs		Q15334	P15529
PDB IDs			1CKL 1HR4 2O39 3INB 3L89 3O8E
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Positive Regulation Of Single-stranded Telomeric DNA Binding Cerebellar Molecular Layer Development Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Vestibular Nucleus Development Positive Regulation Of Eosinophil Degranulation Regulation Of Insulin Secretion Response To Stress Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Peptide Hormone Secretion Gamma-aminobutyric Acid Secretion Regulation Of Hormone Secretion Cellular Protein Localization Interleukin-10 Production Regulation Of Acetylcholine Secretion, Neurotransmission Telomere Assembly Protection From Non-homologous End Joining At Telomere Positive Regulation Of Regulatory T Cell Differentiation Telomere Capping Rhythmic Synaptic Transmission Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cell Activation Regulation Of Synaptic Transmission Positive Regulation Of Telomerase Activity Exocytosis Positive Regulation Of Protein Localization To Cell Surface Sequestering Of Extracellular Ligand From Receptor Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Gamma-aminobutyric Acid Transport Regulation Of Memory T Cell Differentiation Chloride Ion Homeostasis Regulation Of Protein Secretion Negative Regulation Of Telomere Maintenance SNARE Complex Assembly Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Hormone Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Pons Development Cellular Component Assembly Protein Localization Regulation Of Cellular Component Organization	Regulation Of Endocytosis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Vesicle-mediated Transport Axon Guidance Cell Development Neuron Development Maintenance Of Cell Polarity Cell Morphogenesis Negative Regulation Of Anoikis Neuron Differentiation Cell Projection Organization Regulation Of Anoikis Locomotion Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Immune System Process Actin Cytoskeleton Organization Chemotaxis Cortical Actin Cytoskeleton Organization Actin Filament-based Process Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Permeability Generation Of Neurons Golgi To Plasma Membrane Transport Peptidyl-tyrosine Autophosphorylation Neurogenesis Cell Migration Regulation Of Immune Response Cell Motility Cellular Component Assembly Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Adhesion Protein Complex Assembly Dendrite Morphogenesis Immune System Process T Cell Costimulation Blood Coagulation Cytoskeleton Organization
Tagcloud ?		apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages nanog outer pard6b phosphorylating polarity polarization prkcz rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	abc accelerating acinar apical cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Difference) ?		blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages nanog outer pard6b phosphorylating polarity polarization prkcz rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap	abc accelerating acinar cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Intersection) ?		apical