KCNH2 and NDUFS6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCNH2	NDUFS6
Gene Name		potassium channel, voltage gated eag related subfamily H, member 2	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity
	Biological Process	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export	Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Multicellular Organismal Aging Respiratory Electron Transport Chain Multicellular Organism Growth Cellular Metabolic Process Small Molecule Metabolic Process Reproductive System Development Mitochondrion Morphogenesis Cardiovascular System Development
Pathways		Potassium Channels Voltage gated Potassium channels	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs		Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole	NADH
Diseases
GWAS		Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH	5 interactors: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2
Entrez ID		3757	4726
HPRD ID		01069	10356
Ensembl ID		ENSG00000055118
Uniprot IDs		Q12809 Q15BH2	O75380 Q6IBC4
PDB IDs		1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport	Signal Transduction By Phosphorylation MAPK Cascade Phosphorylation Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity JNK Cascade Regulation Of MAPK Cascade Negative Regulation Of Potassium Ion Export Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Membrane Depolarization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Hormone Positive Regulation Of Phosphorylation Regulation Of JNK Cascade Positive Regulation Of Protein Modification Process Cell-cell Signaling Signal Transduction Peptidyl-amino Acid Modification Regulation Of Stress-activated MAPK Cascade Signaling Regulation Of Protein Phosphorylation Cell Communication Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Nonassociative Learning Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Alveolar Secondary Septum Development Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Axonogenesis Involved In Innervation Positive Regulation Of Signal Transduction Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Phosphorylation Defense Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cellular Response To Stimulus Chondrocyte Proliferation Peptidyl-histidine Phosphorylation
Tagcloud ?		1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie	abnormality albuminuria cystatin defects defence deficiency electrochemical excretion f2t glomerular gt hallmarks impairment inner innovation interruption isoprostane juvenile kim mitochondrial modest nitrotyrosine oxidized partial renal respiratory se superoxide
Tagcloud (Difference) ?		1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie	abnormality albuminuria cystatin defects defence deficiency electrochemical excretion f2t glomerular gt hallmarks impairment inner innovation interruption isoprostane juvenile kim mitochondrial modest nitrotyrosine oxidized partial renal respiratory se superoxide
Tagcloud (Intersection) ?