KCNH2 and RHOH

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		KCNH2	RHOH
Description		potassium voltage-gated channel subfamily H member 2	ras homolog family member H
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex	Immunological Synapse Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding Monoatomic Ion Channel Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding
	Biological Process	Regulation Of Heart Rate By Hormone Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of DNA-templated Transcription Potassium Ion Homeostasis Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation	RHOH GTPase cycle
Drugs		Fluvoxamine Erythromycin Dofetilide Enflurane Phenytoin Amsacrine Disopyramide Ibutilide Amitriptyline Terfenadine Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Hydroxyzine Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Loperamide Quinidine Ketoconazole Procainamide Promethazine Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Vanoxerine Dronedarone Azimilide Sertindole Silodosin Vernakalant Tecastemizole Potassium nitrate Pentoxyverine Chlorobutanol Isavuconazole Pitolisant
Diseases		Short QT syndrome Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 20062061) Electrocardiographic traits (multivariate) ( 32602732) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 29213071 29874175 24952745 23166209 30679814 19305409 19305408) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)	Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		11 interacting genes: ALG10 ALG10B CDC73 FRMD8 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH	23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1
Entrez ID		3757	399
HPRD ID		01069	03616
Ensembl ID		ENSG00000055118	ENSG00000168421
Uniprot IDs		A0A090N7W1 A0A090N7X5 A0A090N8Q0 A0AAQ5BGQ9 Q12809 Q15BH2	Q15669 Q6ICP4
PDB IDs		1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3 6SYG 8IO4 8IO5 8IOB 8ZYN 8ZYO 8ZYP 8ZYQ 9CHP 9CHQ 9CHR 9CHS
Enriched GO Terms of Interacting Partners?		Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Repolarization Transmembrane Transporter Binding Regulation Of Membrane Repolarization Regulation Of Metal Ion Transport Regulation Of Heart Rate By Cardiac Conduction Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transport Cardiac Conduction Regulation Of Membrane Potential Regulation Of Heart Contraction Neural Nucleus Development Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Monoatomic Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Intracellular Potassium Ion Homeostasis Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Transporter Activity Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Regulation Of Protein Export From Nucleus Cardiac Muscle Cell Action Potential Regulation Of System Process Regulation Of Biological Quality Protein Domain Specific Binding Substantia Nigra Development	Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction
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